Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

ABSTRACT Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical stra...

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Autores principales: Alexander L. Greninger, Pavitra Roychoudhury, Hong Xie, Amanda Casto, Anne Cent, Gregory Pepper, David M. Koelle, Meei-Li Huang, Anna Wald, Christine Johnston, Keith R. Jerome
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
HSV-1
HSV-2
capture sequencing
culture
dual-strain infection
genomics
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/aca057712f6146b89f7b256106b240d2
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