Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden

Abstract Background Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence trends for MPM remain poorly characteriz...

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Autores principales:	Kari Hemminki, Asta Försti, Tianhui Chen, Akseli Hemminki
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Incidence trends Regional incidence Risk factors Age-specific incidence Birth cohort analysis Relative survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/aca29a5853a44df3b2c9e1d06790ff74
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spelling	oai:doaj.org-article:aca29a5853a44df3b2c9e1d06790ff742021-11-14T12:29:45ZIncidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden10.1186/s12885-021-08913-21471-2407https://doaj.org/article/aca29a5853a44df3b2c9e1d06790ff742021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08913-2https://doaj.org/toc/1471-2407Abstract Background Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence trends for MPM remain poorly characterized. We use nationwide MPM data for Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) to assess incidence, mortality and survival trends for MPM in these countries. Methods We use the NORDCAN database for the analyses: incidence data were available from 1943 in DK, 1953 in FI and NO and 1958 in SE, through 2016. Survival data were available from 1967 through 2016. World standard population was used in age standardization. Results The lowest incidence that we recorded for MPM was 0.02/100,000 for NO women and 0.05/100,000 for FI men in 1953–57, marking the incidence before the influence of asbestos. The highest rate of 1.9/100,000 was recorded for DK in 1997. Female incidence was much lower than male incidence. In each country, the male incidence trend for MPM culminated, first in SE around 1990. The regional incidence trends matched with earlier asbestos-related industrial activity, shipbuilding in FI and SE, cement manufacturing and shipbuilding in DK and seafaring in NO. Relative 1-year survival increased from about 20 to 50% but 5-year survival remained at or below 10%. Conclusion In the Nordic countries, the male incidence trends for MPM climaxed and started to decrease, indicating that the prevention of exposure was beneficial. Survival in MPM has improved for both sexes but long-term survival remains dismal.Kari HemminkiAsta FörstiTianhui ChenAkseli HemminkiBMCarticleIncidence trendsRegional incidenceRisk factorsAge-specific incidenceBirth cohort analysisRelative survivalNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Incidence trends Regional incidence Risk factors Age-specific incidence Birth cohort analysis Relative survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Incidence trends Regional incidence Risk factors Age-specific incidence Birth cohort analysis Relative survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kari Hemminki Asta Försti Tianhui Chen Akseli Hemminki Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
description	Abstract Background Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is largely caused by exposure to asbestos. Reliable information about the incidence of MPM prior the influence of asbestos is lacking. The nationwide regional incidence trends for MPM remain poorly characterized. We use nationwide MPM data for Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE) to assess incidence, mortality and survival trends for MPM in these countries. Methods We use the NORDCAN database for the analyses: incidence data were available from 1943 in DK, 1953 in FI and NO and 1958 in SE, through 2016. Survival data were available from 1967 through 2016. World standard population was used in age standardization. Results The lowest incidence that we recorded for MPM was 0.02/100,000 for NO women and 0.05/100,000 for FI men in 1953–57, marking the incidence before the influence of asbestos. The highest rate of 1.9/100,000 was recorded for DK in 1997. Female incidence was much lower than male incidence. In each country, the male incidence trend for MPM culminated, first in SE around 1990. The regional incidence trends matched with earlier asbestos-related industrial activity, shipbuilding in FI and SE, cement manufacturing and shipbuilding in DK and seafaring in NO. Relative 1-year survival increased from about 20 to 50% but 5-year survival remained at or below 10%. Conclusion In the Nordic countries, the male incidence trends for MPM climaxed and started to decrease, indicating that the prevention of exposure was beneficial. Survival in MPM has improved for both sexes but long-term survival remains dismal.
format	article
author	Kari Hemminki Asta Försti Tianhui Chen Akseli Hemminki
author_facet	Kari Hemminki Asta Försti Tianhui Chen Akseli Hemminki
author_sort	Kari Hemminki
title	Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
title_short	Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
title_full	Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
title_fullStr	Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
title_full_unstemmed	Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
title_sort	incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in denmark, finland, norway and sweden
publisher	BMC
publishDate	2021
url	https://doaj.org/article/aca29a5853a44df3b2c9e1d06790ff74
work_keys_str_mv	AT karihemminki incidencemortalityandsurvivalinmalignantpleuralmesotheliomabeforeandafterasbestosindenmarkfinlandnorwayandsweden AT astaforsti incidencemortalityandsurvivalinmalignantpleuralmesotheliomabeforeandafterasbestosindenmarkfinlandnorwayandsweden AT tianhuichen incidencemortalityandsurvivalinmalignantpleuralmesotheliomabeforeandafterasbestosindenmarkfinlandnorwayandsweden AT akselihemminki incidencemortalityandsurvivalinmalignantpleuralmesotheliomabeforeandafterasbestosindenmarkfinlandnorwayandsweden
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Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden

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