Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder

Jia-Quan Liang,1,* Hai-Rong Liao,1,* Cai-Xia Xu,1 Xiao-Ling Li,1 Ze-Xu Wei,2 Guo-Jun Xie,1 Yong Cheng1,2 1Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience, Minzu University of Chi...

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Autores principales:	Liang JQ, Liao HR, Xu CX, Li XL, Wei ZX, Xie GJ, Cheng Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	major depressive disorder exosome mir-139-5p biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/acac5491f86445da930886f7d11d20f0
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spelling	oai:doaj.org-article:acac5491f86445da930886f7d11d20f02021-12-02T15:17:25ZSerum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder1178-2021https://doaj.org/article/acac5491f86445da930886f7d11d20f02020-11-01T00:00:00Zhttps://www.dovepress.com/serum-exosome-derived-mir-139-5p-as-a-potential-biomarker-for-major-de-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jia-Quan Liang,1,* Hai-Rong Liao,1,* Cai-Xia Xu,1 Xiao-Ling Li,1 Ze-Xu Wei,2 Guo-Jun Xie,1 Yong Cheng1,2 1Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience, Minzu University of China, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guo-Jun Xie; Yong Cheng Email xiegjfs@163.com; yongcheng@muc.edu.cnBackground: MicroRNAs (miRs) have been suggested to be biomarkers to inform the diagnosis of major depressive disorder (MDD). We have previously shown that exosome-derived miR-139-5p had potential in differentiating between patients with MDD and healthy control (HC) subjects.Materials and Methods: To validate the potential of exosome-derived miR-139-5p as a biomarker for MDD, here we recruited 30 patients with MDD and 30 HC subjects, and used TaqMan probes to detect serum exosomal miR-139-5p levels.Results: The data showed that patients with MDD had significantly increased exosomal miR-139-5p levels when compared with controls. Correlation analysis suggested that sex, age, and body mass index did not significantly affect blood exosomal miR-139-5p levels in the tested subjects. The ROC curve showed that serum-derived miR-139-5p had reasonable performance in discriminating patients with MDD and HC subjects, with a sensitivity of 0.867 and specificity of 0.767, and the AUC was 0.807.Discussion: Taken together, these results demonstrated that patients with MDD were accompanied by significantly increased blood exosomal miR-139-5p levels, and exosomal miR-139-5p is a promising biomarker for the diagnosis of MDD.Keywords: major depressive disorder, exosome, miR-139-5p, biomarkerLiang JQLiao HRXu CXLi XLWei ZXXie GJCheng YDove Medical Pressarticlemajor depressive disorderexosomemir-139-5pbiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2689-2693 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	major depressive disorder exosome mir-139-5p biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	major depressive disorder exosome mir-139-5p biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liang JQ Liao HR Xu CX Li XL Wei ZX Xie GJ Cheng Y Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
description	Jia-Quan Liang,1,* Hai-Rong Liao,1,* Cai-Xia Xu,1 Xiao-Ling Li,1 Ze-Xu Wei,2 Guo-Jun Xie,1 Yong Cheng1,2 1Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience, Minzu University of China, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guo-Jun Xie; Yong Cheng Email xiegjfs@163.com; yongcheng@muc.edu.cnBackground: MicroRNAs (miRs) have been suggested to be biomarkers to inform the diagnosis of major depressive disorder (MDD). We have previously shown that exosome-derived miR-139-5p had potential in differentiating between patients with MDD and healthy control (HC) subjects.Materials and Methods: To validate the potential of exosome-derived miR-139-5p as a biomarker for MDD, here we recruited 30 patients with MDD and 30 HC subjects, and used TaqMan probes to detect serum exosomal miR-139-5p levels.Results: The data showed that patients with MDD had significantly increased exosomal miR-139-5p levels when compared with controls. Correlation analysis suggested that sex, age, and body mass index did not significantly affect blood exosomal miR-139-5p levels in the tested subjects. The ROC curve showed that serum-derived miR-139-5p had reasonable performance in discriminating patients with MDD and HC subjects, with a sensitivity of 0.867 and specificity of 0.767, and the AUC was 0.807.Discussion: Taken together, these results demonstrated that patients with MDD were accompanied by significantly increased blood exosomal miR-139-5p levels, and exosomal miR-139-5p is a promising biomarker for the diagnosis of MDD.Keywords: major depressive disorder, exosome, miR-139-5p, biomarker
format	article
author	Liang JQ Liao HR Xu CX Li XL Wei ZX Xie GJ Cheng Y
author_facet	Liang JQ Liao HR Xu CX Li XL Wei ZX Xie GJ Cheng Y
author_sort	Liang JQ
title	Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
title_short	Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
title_full	Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
title_fullStr	Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
title_full_unstemmed	Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
title_sort	serum exosome-derived mir-139-5p as a potential biomarker for major depressive disorder
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/acac5491f86445da930886f7d11d20f0
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Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder

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