Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes

Hyperglycemia, when sustained over a long time in diabetes mellitus (DM), leads to biochemical and cellular abnormalities, primarily through the formation of advanced glycation end-products (AGEs). In the treatment of diabetes, beside blood-sugar-lowering medications, a consumption of herbal product...

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Autores principales:	Arleta Dołowacka-Jóźwiak, Adam Matkowski, Izabela Nawrot-Hadzik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus <i>Reynoutria</i> <i>Polygoni cuspidati rhizoma</i> polyphenols protein glycation advanced glycation endproducts Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/acad058bd7c0442993cb59f604920724
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spelling	oai:doaj.org-article:acad058bd7c0442993cb59f6049207242021-11-25T18:36:30ZAntiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes10.3390/nu131140662072-6643https://doaj.org/article/acad058bd7c0442993cb59f6049207242021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4066https://doaj.org/toc/2072-6643Hyperglycemia, when sustained over a long time in diabetes mellitus (DM), leads to biochemical and cellular abnormalities, primarily through the formation of advanced glycation end-products (AGEs). In the treatment of diabetes, beside blood-sugar-lowering medications, a consumption of herbal products that can inhibit the AGEs’ formation is recommended. This study investigated the in vitro antiglycoxidative potential of extracts and fractions from the rhizomes of Japanese, Giant, and Bohemian knotweeds (<i>Reynoutria japonica</i> (Houtt.), <i>R. sachalinensis</i> (F. Schmidt) Nakai, and <i>R.</i>× <i>bohemica</i> Chrtek et Chrtkova). Their effects on glycooxidation of bovine and human serum albumin were evaluated by incubation of the proteins with a mixture of glucose and fructose (0.5 M) and 150 µg/mL of extract for 28 days at 37 °C, followed by measuring early and late glycation products, albumin oxidation (carbonyl and free thiol groups), and amyloid-β aggregation (thioflavin T and Congo red assays). The highest antiglycoxidative activity, comparable or stronger than the reference drug (aminoguanidine), was observed for ethyl acetate and diethyl ether fractions, enriched in polyphenols (stilbenes, phenylpropanoid disaccharide esters, and free and oligomeric flavan-3-ols). In conclusion, the antiglycoxidative compounds from these three species should be further studied for potential use in the prevention and complementary treatment of DM.Arleta Dołowacka-JóźwiakAdam MatkowskiIzabela Nawrot-HadzikMDPI AGarticlediabetes mellitus<i>Reynoutria</i><i>Polygoni cuspidati rhizoma</i>polyphenolsprotein glycationadvanced glycation endproductsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4066, p 4066 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus <i>Reynoutria</i> <i>Polygoni cuspidati rhizoma</i> polyphenols protein glycation advanced glycation endproducts Nutrition. Foods and food supply TX341-641
spellingShingle	diabetes mellitus <i>Reynoutria</i> <i>Polygoni cuspidati rhizoma</i> polyphenols protein glycation advanced glycation endproducts Nutrition. Foods and food supply TX341-641 Arleta Dołowacka-Jóźwiak Adam Matkowski Izabela Nawrot-Hadzik Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
description	Hyperglycemia, when sustained over a long time in diabetes mellitus (DM), leads to biochemical and cellular abnormalities, primarily through the formation of advanced glycation end-products (AGEs). In the treatment of diabetes, beside blood-sugar-lowering medications, a consumption of herbal products that can inhibit the AGEs’ formation is recommended. This study investigated the in vitro antiglycoxidative potential of extracts and fractions from the rhizomes of Japanese, Giant, and Bohemian knotweeds (<i>Reynoutria japonica</i> (Houtt.), <i>R. sachalinensis</i> (F. Schmidt) Nakai, and <i>R.</i>× <i>bohemica</i> Chrtek et Chrtkova). Their effects on glycooxidation of bovine and human serum albumin were evaluated by incubation of the proteins with a mixture of glucose and fructose (0.5 M) and 150 µg/mL of extract for 28 days at 37 °C, followed by measuring early and late glycation products, albumin oxidation (carbonyl and free thiol groups), and amyloid-β aggregation (thioflavin T and Congo red assays). The highest antiglycoxidative activity, comparable or stronger than the reference drug (aminoguanidine), was observed for ethyl acetate and diethyl ether fractions, enriched in polyphenols (stilbenes, phenylpropanoid disaccharide esters, and free and oligomeric flavan-3-ols). In conclusion, the antiglycoxidative compounds from these three species should be further studied for potential use in the prevention and complementary treatment of DM.
format	article
author	Arleta Dołowacka-Jóźwiak Adam Matkowski Izabela Nawrot-Hadzik
author_facet	Arleta Dołowacka-Jóźwiak Adam Matkowski Izabela Nawrot-Hadzik
author_sort	Arleta Dołowacka-Jóźwiak
title	Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
title_short	Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
title_full	Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
title_fullStr	Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
title_full_unstemmed	Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes
title_sort	antiglycoxidative properties of extracts and fractions from <i>reynoutria</i> rhizomes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/acad058bd7c0442993cb59f604920724
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Antiglycoxidative Properties of Extracts and Fractions from <i>Reynoutria</i> Rhizomes

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