CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION

Hematopoietic stem cell transplantation (HSCT) from healthy donors is used for blood cancer treatment. Alloreactive graft-versus-host disease (GvHD) is one of the post-transplant detrimental side effects, and the main reason for GVHD after HSCT fully matched for human leukocyte peptide antigens (HLA...

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Autores principales:	D. S. Romaniuk, A. A. Khmelevskaya, A. M. Postovskaya, D. B. Malko, E. P. Kuzminova, E. G. Khamaganova, G. A. Efimov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	minor histocompatibility antigen miha ha-1 snp asp allele-specific primer as-qpcr allele-specific qpcr gvhd gvl Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/acb19400962042fc9d8c8f2a9f51bf90
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spelling	oai:doaj.org-article:acb19400962042fc9d8c8f2a9f51bf902021-11-18T08:03:48ZCLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION1563-06252313-741X10.15789/1563-0625-2019-5-847-860https://doaj.org/article/acb19400962042fc9d8c8f2a9f51bf902019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1660https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XHematopoietic stem cell transplantation (HSCT) from healthy donors is used for blood cancer treatment. Alloreactive graft-versus-host disease (GvHD) is one of the post-transplant detrimental side effects, and the main reason for GVHD after HSCT fully matched for human leukocyte peptide antigens (HLA) presented by HLA molecules on cell surface. These polymorphic peptides, minor histocompatibility antigens (MiHA), arise from any genes, including those expressed at hematopoietic tissues. The latter may lead to the s.c. graft-versus-leukemia effect (GvL), thus preventing relapse of a malignancy. A02:01 is one of the most frequent HLA alleles for European part of Russia. We assessed frequencies for 20 MiHA-encoded genetic polymorphisms, presented via A02:01 allele, for plausible bone marrow donors, or hematopoietic stem cells (HSC) from the Donor Registry at Russian National Research Center for Hematology, we have also determined a number of immunogenic mismatches for these 20 MiHA in real donor – recipient pairs. A total of 608 potential donors, 90 donors and 92 recipients were genotyped. Using public data, we have shown that frequencies for MiHA coding genes are most close to appropriate frequencies among the European population. We have calculated probability of MiHA-specific alloimmune response after HSCT: there are chances of 33 and 75% for three or more immunogenic mismatches (IM) for related and unrelated HSCTs, respectively. Real frequencies for immune mismatch in 20 related and 20 unrelated donor – recipient pairs are in accordance with estimated theoretical probabilities. As based on the calculated frequencies, we suggest the LB-NDC80- 1P/A, LB-CCL4- 1T, and HA-1 MiHA to be the most promising minor antigens for targeted cell therapies of hematopoietic tissue malignancies. The data obtained could be used for planning allo-HSCTs in Russian patients.D. S. RomaniukA. A. KhmelevskayaA. M. PostovskayaD. B. MalkoE. P. KuzminovaE. G. KhamaganovaG. A. EfimovSPb RAACIarticleminor histocompatibility antigenmihaha-1snpaspallele-specific primeras-qpcrallele-specific qpcrgvhdgvlImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 847-860 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	minor histocompatibility antigen miha ha-1 snp asp allele-specific primer as-qpcr allele-specific qpcr gvhd gvl Immunologic diseases. Allergy RC581-607
spellingShingle	minor histocompatibility antigen miha ha-1 snp asp allele-specific primer as-qpcr allele-specific qpcr gvhd gvl Immunologic diseases. Allergy RC581-607 D. S. Romaniuk A. A. Khmelevskaya A. M. Postovskaya D. B. Malko E. P. Kuzminova E. G. Khamaganova G. A. Efimov CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
description	Hematopoietic stem cell transplantation (HSCT) from healthy donors is used for blood cancer treatment. Alloreactive graft-versus-host disease (GvHD) is one of the post-transplant detrimental side effects, and the main reason for GVHD after HSCT fully matched for human leukocyte peptide antigens (HLA) presented by HLA molecules on cell surface. These polymorphic peptides, minor histocompatibility antigens (MiHA), arise from any genes, including those expressed at hematopoietic tissues. The latter may lead to the s.c. graft-versus-leukemia effect (GvL), thus preventing relapse of a malignancy. A02:01 is one of the most frequent HLA alleles for European part of Russia. We assessed frequencies for 20 MiHA-encoded genetic polymorphisms, presented via A02:01 allele, for plausible bone marrow donors, or hematopoietic stem cells (HSC) from the Donor Registry at Russian National Research Center for Hematology, we have also determined a number of immunogenic mismatches for these 20 MiHA in real donor – recipient pairs. A total of 608 potential donors, 90 donors and 92 recipients were genotyped. Using public data, we have shown that frequencies for MiHA coding genes are most close to appropriate frequencies among the European population. We have calculated probability of MiHA-specific alloimmune response after HSCT: there are chances of 33 and 75% for three or more immunogenic mismatches (IM) for related and unrelated HSCTs, respectively. Real frequencies for immune mismatch in 20 related and 20 unrelated donor – recipient pairs are in accordance with estimated theoretical probabilities. As based on the calculated frequencies, we suggest the LB-NDC80- 1P/A, LB-CCL4- 1T, and HA-1 MiHA to be the most promising minor antigens for targeted cell therapies of hematopoietic tissue malignancies. The data obtained could be used for planning allo-HSCTs in Russian patients.
format	article
author	D. S. Romaniuk A. A. Khmelevskaya A. M. Postovskaya D. B. Malko E. P. Kuzminova E. G. Khamaganova G. A. Efimov
author_facet	D. S. Romaniuk A. A. Khmelevskaya A. M. Postovskaya D. B. Malko E. P. Kuzminova E. G. Khamaganova G. A. Efimov
author_sort	D. S. Romaniuk
title	CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_short	CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full	CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_fullStr	CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_full_unstemmed	CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION
title_sort	clinically relevant minor histocompatibility antigens for russian patients undergoing hematopoietic stem cell transplantation
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/acb19400962042fc9d8c8f2a9f51bf90
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CLINICALLY RELEVANT MINOR HISTOCOMPATIBILITY ANTIGENS FOR RUSSIAN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION

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