Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties

Abstract The prevalence of arrhythmia in patients with hypertension has gradually attracted widespread attention. However, the relationship between hypertension and arrhythmia still lacks more attention. Herein, we explore the biomechanical mechanism of arrhythmia in hypertensive rats and the effect...

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Autores principales:	Yifeng Nie, Yin He, Dong Han, Yuansheng Liu, Xiang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acb3237cf18e4eddbd993e8ca2f44f50
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spelling	oai:doaj.org-article:acb3237cf18e4eddbd993e8ca2f44f502021-12-02T16:18:06ZAmiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties10.1038/s41598-020-78677-52045-2322https://doaj.org/article/acb3237cf18e4eddbd993e8ca2f44f502020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78677-5https://doaj.org/toc/2045-2322Abstract The prevalence of arrhythmia in patients with hypertension has gradually attracted widespread attention. However, the relationship between hypertension and arrhythmia still lacks more attention. Herein, we explore the biomechanical mechanism of arrhythmia in hypertensive rats and the effect of amiodarone on biomechanical properties. We applied micro-mechanics and amiodarone to stimulate single ventricular myocytes to compare changes of mechanical parameters and the mechanism was investigated in biomechanics. Then we verified the expression changes of genes and long non-coding RNAs (lncRNAs) related to myocardial mechanics to explore the effect of amiodarone on biomechanical properties. The results found that the stiffness of ventricular myocytes and calcium ion levels in hypertensive rats were significantly increased and amiodarone could alleviate the intracellular calcium response and biomechanical stimulation. In addition, experiments showed spontaneously hypertensive rats were more likely to induce arrhythmia and preoperative amiodarone intervention significantly reduced the occurrence of arrhythmias. Meanwhile, high-throughput sequencing showed the genes and lncRNAs related to myocardial mechanics changed significantly in the spontaneously hypertensive rats that amiodarone was injected. These results strengthen the evidence that hypertension rats are prone to arrhythmia with abnormal myocardial biomechanical properties. Amiodarone effectively inhibit arrhythmia by improving the myocardial biomechanical properties and weakening the sensitivity of mechanical stretch stimulation.Yifeng NieYin HeDong HanYuansheng LiuXiang LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yifeng Nie Yin He Dong Han Yuansheng Liu Xiang Li Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
description	Abstract The prevalence of arrhythmia in patients with hypertension has gradually attracted widespread attention. However, the relationship between hypertension and arrhythmia still lacks more attention. Herein, we explore the biomechanical mechanism of arrhythmia in hypertensive rats and the effect of amiodarone on biomechanical properties. We applied micro-mechanics and amiodarone to stimulate single ventricular myocytes to compare changes of mechanical parameters and the mechanism was investigated in biomechanics. Then we verified the expression changes of genes and long non-coding RNAs (lncRNAs) related to myocardial mechanics to explore the effect of amiodarone on biomechanical properties. The results found that the stiffness of ventricular myocytes and calcium ion levels in hypertensive rats were significantly increased and amiodarone could alleviate the intracellular calcium response and biomechanical stimulation. In addition, experiments showed spontaneously hypertensive rats were more likely to induce arrhythmia and preoperative amiodarone intervention significantly reduced the occurrence of arrhythmias. Meanwhile, high-throughput sequencing showed the genes and lncRNAs related to myocardial mechanics changed significantly in the spontaneously hypertensive rats that amiodarone was injected. These results strengthen the evidence that hypertension rats are prone to arrhythmia with abnormal myocardial biomechanical properties. Amiodarone effectively inhibit arrhythmia by improving the myocardial biomechanical properties and weakening the sensitivity of mechanical stretch stimulation.
format	article
author	Yifeng Nie Yin He Dong Han Yuansheng Liu Xiang Li
author_facet	Yifeng Nie Yin He Dong Han Yuansheng Liu Xiang Li
author_sort	Yifeng Nie
title	Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
title_short	Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
title_full	Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
title_fullStr	Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
title_full_unstemmed	Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
title_sort	amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/acb3237cf18e4eddbd993e8ca2f44f50
work_keys_str_mv	AT yifengnie amiodaroneinhibitsarrhythmiasinhypertensiveratsbyimprovingmyocardialbiomechanicalproperties AT yinhe amiodaroneinhibitsarrhythmiasinhypertensiveratsbyimprovingmyocardialbiomechanicalproperties AT donghan amiodaroneinhibitsarrhythmiasinhypertensiveratsbyimprovingmyocardialbiomechanicalproperties AT yuanshengliu amiodaroneinhibitsarrhythmiasinhypertensiveratsbyimprovingmyocardialbiomechanicalproperties AT xiangli amiodaroneinhibitsarrhythmiasinhypertensiveratsbyimprovingmyocardialbiomechanicalproperties
_version_	1718384191737954304

Amiodarone inhibits arrhythmias in hypertensive rats by improving myocardial biomechanical properties

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