The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metapha...

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Autores principales: Sang-Min Jang, Jenny F. Nathans, Haiqing Fu, Christophe E. Redon, Lisa M. Jenkins, Bhushan L. Thakur, Lőrinc S. Pongor, Adrian M. Baris, Jacob M. Gross, Maura J. OʹNeill, Fred E. Indig, Steven D. Cappell, Mirit I. Aladjem
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/acb64edefaf545c091ce4db99899a6a3
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spelling oai:doaj.org-article:acb64edefaf545c091ce4db99899a6a32021-12-02T14:42:30ZThe RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation10.1038/s41467-019-13808-92041-1723https://doaj.org/article/acb64edefaf545c091ce4db99899a6a32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13808-9https://doaj.org/toc/2041-1723The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.Sang-Min JangJenny F. NathansHaiqing FuChristophe E. RedonLisa M. JenkinsBhushan L. ThakurLőrinc S. PongorAdrian M. BarisJacob M. GrossMaura J. OʹNeillFred E. IndigSteven D. CappellMirit I. AladjemNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sang-Min Jang
Jenny F. Nathans
Haiqing Fu
Christophe E. Redon
Lisa M. Jenkins
Bhushan L. Thakur
Lőrinc S. Pongor
Adrian M. Baris
Jacob M. Gross
Maura J. OʹNeill
Fred E. Indig
Steven D. Cappell
Mirit I. Aladjem
The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
description The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.
format article
author Sang-Min Jang
Jenny F. Nathans
Haiqing Fu
Christophe E. Redon
Lisa M. Jenkins
Bhushan L. Thakur
Lőrinc S. Pongor
Adrian M. Baris
Jacob M. Gross
Maura J. OʹNeill
Fred E. Indig
Steven D. Cappell
Mirit I. Aladjem
author_facet Sang-Min Jang
Jenny F. Nathans
Haiqing Fu
Christophe E. Redon
Lisa M. Jenkins
Bhushan L. Thakur
Lőrinc S. Pongor
Adrian M. Baris
Jacob M. Gross
Maura J. OʹNeill
Fred E. Indig
Steven D. Cappell
Mirit I. Aladjem
author_sort Sang-Min Jang
title The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
title_short The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
title_full The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
title_fullStr The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
title_full_unstemmed The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
title_sort repid–crl4 ubiquitin ligase complex regulates metaphase to anaphase transition via bub3 degradation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/acb64edefaf545c091ce4db99899a6a3
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