Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins. Here the authors investigate the role of TRAK2 as a bidirectional motor adaptor, and propose a model where TRAK2 coordinates the activities of o...

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Autores principales:	Adam R. Fenton, Thomas A. Jongens, Erika L. F. Holzbaur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acb6e48bd1c84d51b3fcfa57aca067cf
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spelling	oai:doaj.org-article:acb6e48bd1c84d51b3fcfa57aca067cf2021-12-02T16:30:15ZMitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors10.1038/s41467-021-24862-72041-1723https://doaj.org/article/acb6e48bd1c84d51b3fcfa57aca067cf2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24862-7https://doaj.org/toc/2041-1723Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins. Here the authors investigate the role of TRAK2 as a bidirectional motor adaptor, and propose a model where TRAK2 coordinates the activities of opposing kinesin-1 and cytoplasmic dynein motors as a single interdependent motor complex.Adam R. FentonThomas A. JongensErika L. F. HolzbaurNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam R. Fenton Thomas A. Jongens Erika L. F. Holzbaur Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
description	Mitochondrial transport toward both the plus- and minus-ends of microtubules is mediated by motor proteins linked to mitochondria by TRAK adaptor proteins. Here the authors investigate the role of TRAK2 as a bidirectional motor adaptor, and propose a model where TRAK2 coordinates the activities of opposing kinesin-1 and cytoplasmic dynein motors as a single interdependent motor complex.
format	article
author	Adam R. Fenton Thomas A. Jongens Erika L. F. Holzbaur
author_facet	Adam R. Fenton Thomas A. Jongens Erika L. F. Holzbaur
author_sort	Adam R. Fenton
title	Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
title_short	Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
title_full	Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
title_fullStr	Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
title_full_unstemmed	Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
title_sort	mitochondrial adaptor trak2 activates and functionally links opposing kinesin and dynein motors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acb6e48bd1c84d51b3fcfa57aca067cf
work_keys_str_mv	AT adamrfenton mitochondrialadaptortrak2activatesandfunctionallylinksopposingkinesinanddyneinmotors AT thomasajongens mitochondrialadaptortrak2activatesandfunctionallylinksopposingkinesinanddyneinmotors AT erikalfholzbaur mitochondrialadaptortrak2activatesandfunctionallylinksopposingkinesinanddyneinmotors
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Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

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