Binding of HMGN proteins to cell specific enhancers stabilizes cell identity

HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity.

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Autores principales:	Bing He, Tao Deng, Iris Zhu, Takashi Furusawa, Shaofei Zhang, Wei Tang, Yuri Postnikov, Stefan Ambs, Caiyi Cherry Li, Ferenc Livak, David Landsman, Michael Bustin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acb87ff987c14ca2b815b9f6f7ffe5ff
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spelling	oai:doaj.org-article:acb87ff987c14ca2b815b9f6f7ffe5ff2021-12-02T14:39:04ZBinding of HMGN proteins to cell specific enhancers stabilizes cell identity10.1038/s41467-018-07687-92041-1723https://doaj.org/article/acb87ff987c14ca2b815b9f6f7ffe5ff2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07687-9https://doaj.org/toc/2041-1723HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity.Bing HeTao DengIris ZhuTakashi FurusawaShaofei ZhangWei TangYuri PostnikovStefan AmbsCaiyi Cherry LiFerenc LivakDavid LandsmanMichael BustinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
description	HMGN1 and HMGN2 are ubiquitous nucleosome binding proteins. Here the authors provide evidence that HMGN proteins preferentially localize to chromatin regulatory sites to modulate the plasticity of the epigenetic landscape, proposing that HGMNs stabilize, rather than determine, cell identity.
format	article
author	Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin
author_facet	Bing He Tao Deng Iris Zhu Takashi Furusawa Shaofei Zhang Wei Tang Yuri Postnikov Stefan Ambs Caiyi Cherry Li Ferenc Livak David Landsman Michael Bustin
author_sort	Bing He
title	Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
title_short	Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
title_full	Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
title_fullStr	Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
title_full_unstemmed	Binding of HMGN proteins to cell specific enhancers stabilizes cell identity
title_sort	binding of hmgn proteins to cell specific enhancers stabilizes cell identity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/acb87ff987c14ca2b815b9f6f7ffe5ff
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Binding of HMGN proteins to cell specific enhancers stabilizes cell identity

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