Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions

The Gram-negative bacterium Vibrio cholerae is responsible for the severe diarrheal pandemic disease cholera, representing a major global public health concern. This pathogen transitions from aquatic reservoirs into epidemics in human populations, and has evolved numerous mechanisms to sense this tr...

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Autores principales:	Ansel Hsiao, Jun Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	vibrio cholerae virulence factors microbiome quorum sensing bile salts anaerobiosis small intestine t6ss Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/acba0b992a5a415ab8b38ffd48893670
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spelling	oai:doaj.org-article:acba0b992a5a415ab8b38ffd488936702021-11-17T14:21:59ZPathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions2150-55942150-560810.1080/21505594.2020.1845039https://doaj.org/article/acba0b992a5a415ab8b38ffd488936702020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1845039https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608The Gram-negative bacterium Vibrio cholerae is responsible for the severe diarrheal pandemic disease cholera, representing a major global public health concern. This pathogen transitions from aquatic reservoirs into epidemics in human populations, and has evolved numerous mechanisms to sense this transition in order to appropriately regulate its gene expression for infection. At the intersection of pathogen and host in the gastrointestinal tract lies the community of native gut microbes, the gut microbiome. It is increasingly clear that the diversity of species and biochemical activities within the gut microbiome represents a driver of infection outcome, through their ability to manipulate the signals used by V. cholerae to regulate virulence and fitness in vivo. A better mechanistic understanding of how commensal microbial action interacts with V. cholerae pathogenesis may lead to novel prophylactic and therapeutic interventions for cholera. Here, we review a subset of this burgeoning field of research.Ansel HsiaoJun ZhuTaylor & Francis Grouparticlevibrio choleraevirulence factorsmicrobiomequorum sensingbile saltsanaerobiosissmall intestinet6ssInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1582-1599 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	vibrio cholerae virulence factors microbiome quorum sensing bile salts anaerobiosis small intestine t6ss Infectious and parasitic diseases RC109-216
spellingShingle	vibrio cholerae virulence factors microbiome quorum sensing bile salts anaerobiosis small intestine t6ss Infectious and parasitic diseases RC109-216 Ansel Hsiao Jun Zhu Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
description	The Gram-negative bacterium Vibrio cholerae is responsible for the severe diarrheal pandemic disease cholera, representing a major global public health concern. This pathogen transitions from aquatic reservoirs into epidemics in human populations, and has evolved numerous mechanisms to sense this transition in order to appropriately regulate its gene expression for infection. At the intersection of pathogen and host in the gastrointestinal tract lies the community of native gut microbes, the gut microbiome. It is increasingly clear that the diversity of species and biochemical activities within the gut microbiome represents a driver of infection outcome, through their ability to manipulate the signals used by V. cholerae to regulate virulence and fitness in vivo. A better mechanistic understanding of how commensal microbial action interacts with V. cholerae pathogenesis may lead to novel prophylactic and therapeutic interventions for cholera. Here, we review a subset of this burgeoning field of research.
format	article
author	Ansel Hsiao Jun Zhu
author_facet	Ansel Hsiao Jun Zhu
author_sort	Ansel Hsiao
title	Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
title_short	Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
title_full	Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
title_fullStr	Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
title_full_unstemmed	Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions
title_sort	pathogenicity and virulence regulation of vibrio cholerae at the interface of host-gut microbiome interactions
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/acba0b992a5a415ab8b38ffd48893670
work_keys_str_mv	AT anselhsiao pathogenicityandvirulenceregulationofvibriocholeraeattheinterfaceofhostgutmicrobiomeinteractions AT junzhu pathogenicityandvirulenceregulationofvibriocholeraeattheinterfaceofhostgutmicrobiomeinteractions
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Pathogenicity and virulence regulation of Vibrio cholerae at the interface of host-gut microbiome interactions

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