Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci

Abstract Coagulase-negative staphylococci (CoNS) are the most frequent contaminating bacteria; therefore, we aimed to investigate an indicator of CoNS to predict the increase in blood culture contamination rate (ConR). We performed a retrospective study of selected patients, who underwent blood cult...

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Autores principales:	Kei Yamamoto, Kazuhisa Mezaki, Norio Ohmagari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acbe23332b1c432b958de6e869d2364e
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spelling	oai:doaj.org-article:acbe23332b1c432b958de6e869d2364e2021-12-02T16:37:37ZSimple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci10.1038/s41598-021-96997-y2045-2322https://doaj.org/article/acbe23332b1c432b958de6e869d2364e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96997-yhttps://doaj.org/toc/2045-2322Abstract Coagulase-negative staphylococci (CoNS) are the most frequent contaminating bacteria; therefore, we aimed to investigate an indicator of CoNS to predict the increase in blood culture contamination rate (ConR). We performed a retrospective study of selected patients, who underwent blood culture testing. Contamination was defined as the presence of either one of two or more sets of skin-resident bacteria, except for cases with a low likelihood of contamination based on clinical aspects. We calculated the monthly ConR [(total number of contaminated cases per month)/(total number of blood culture sets collected per month) × 100] and analysed the ConR prediction ability using the following four indicators: the number of CoNS-positive sets of blood cultures, cases with at least one CoNS-positive blood culture set, cases with only one CoNS-positive blood culture set, and cases of contamination by CoNS. Cases with CoNS-positive blood cultures correlated with ConR (r = 0.85). Although the area under the receiver operating characteristic curve for the number of cases with ConR ≥ 2.5 differed significantly from that of the number of cases contaminated by CoNS, the negative predictive value was high, reaching up to 95.5% (95% confidential interval 87.3–99.1). The number of CoNS-positive cases could help predict an increase in ConR ≥ 2.5.Kei YamamotoKazuhisa MezakiNorio OhmagariNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kei Yamamoto Kazuhisa Mezaki Norio Ohmagari Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
description	Abstract Coagulase-negative staphylococci (CoNS) are the most frequent contaminating bacteria; therefore, we aimed to investigate an indicator of CoNS to predict the increase in blood culture contamination rate (ConR). We performed a retrospective study of selected patients, who underwent blood culture testing. Contamination was defined as the presence of either one of two or more sets of skin-resident bacteria, except for cases with a low likelihood of contamination based on clinical aspects. We calculated the monthly ConR [(total number of contaminated cases per month)/(total number of blood culture sets collected per month) × 100] and analysed the ConR prediction ability using the following four indicators: the number of CoNS-positive sets of blood cultures, cases with at least one CoNS-positive blood culture set, cases with only one CoNS-positive blood culture set, and cases of contamination by CoNS. Cases with CoNS-positive blood cultures correlated with ConR (r = 0.85). Although the area under the receiver operating characteristic curve for the number of cases with ConR ≥ 2.5 differed significantly from that of the number of cases contaminated by CoNS, the negative predictive value was high, reaching up to 95.5% (95% confidential interval 87.3–99.1). The number of CoNS-positive cases could help predict an increase in ConR ≥ 2.5.
format	article
author	Kei Yamamoto Kazuhisa Mezaki Norio Ohmagari
author_facet	Kei Yamamoto Kazuhisa Mezaki Norio Ohmagari
author_sort	Kei Yamamoto
title	Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
title_short	Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
title_full	Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
title_fullStr	Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
title_full_unstemmed	Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
title_sort	simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acbe23332b1c432b958de6e869d2364e
work_keys_str_mv	AT keiyamamoto simpleindictorofincreasedbloodculturecontaminationratebydetectionofcoagulasenegativestaphylococci AT kazuhisamezaki simpleindictorofincreasedbloodculturecontaminationratebydetectionofcoagulasenegativestaphylococci AT norioohmagari simpleindictorofincreasedbloodculturecontaminationratebydetectionofcoagulasenegativestaphylococci
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Simple indictor of increased blood culture contamination rate by detection of coagulase-negative staphylococci

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