Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing

The synergistic effect of chitosan (CS), glycyrrhizic acid (GA) and ZnO/palygorskite (ZnO/PAL) as potential wound dressing was evaluated in the form of films by the solution casting method. The nanocomposite films were well-characterized with ATR-FTIR, XRD and SEM to explore the interactions between...

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Autores principales:	Qian Zhang, Hong Zhang, Aiping Hui, Junjie Ding, Xinyue Liu, Aiqin Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chitosan glycyrrhizic acid ZnO/PAL antibacterial nanocomposite films Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/acc304183f7041e19697afd4ff6c99a3
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spelling	oai:doaj.org-article:acc304183f7041e19697afd4ff6c99a32021-11-25T18:47:52ZSynergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing10.3390/polym132238782073-4360https://doaj.org/article/acc304183f7041e19697afd4ff6c99a32021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3878https://doaj.org/toc/2073-4360The synergistic effect of chitosan (CS), glycyrrhizic acid (GA) and ZnO/palygorskite (ZnO/PAL) as potential wound dressing was evaluated in the form of films by the solution casting method. The nanocomposite films were well-characterized with ATR-FTIR, XRD and SEM to explore the interactions between CS, GA and ZnO/PAL. Physical, mechanical and antibacterial properties of the nanocomposite films were systematically investigated for their reliability in end-up utilization. Importantly, it was found that the presence of PAL in the films provided enhanced mechanical properties, whereas CS, GA and ZnO supplied a broad-spectrum antibacterial activity, especially for drug-resistant bacteria such as ESBL—<i>E. coli</i> and MRSA. Overall, this research demonstrated that the prepared films can be a promising candidate for wound-care materials.Qian ZhangHong ZhangAiping HuiJunjie DingXinyue LiuAiqin WangMDPI AGarticlechitosanglycyrrhizic acidZnO/PALantibacterialnanocomposite filmsOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3878, p 3878 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan glycyrrhizic acid ZnO/PAL antibacterial nanocomposite films Organic chemistry QD241-441
spellingShingle	chitosan glycyrrhizic acid ZnO/PAL antibacterial nanocomposite films Organic chemistry QD241-441 Qian Zhang Hong Zhang Aiping Hui Junjie Ding Xinyue Liu Aiqin Wang Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
description	The synergistic effect of chitosan (CS), glycyrrhizic acid (GA) and ZnO/palygorskite (ZnO/PAL) as potential wound dressing was evaluated in the form of films by the solution casting method. The nanocomposite films were well-characterized with ATR-FTIR, XRD and SEM to explore the interactions between CS, GA and ZnO/PAL. Physical, mechanical and antibacterial properties of the nanocomposite films were systematically investigated for their reliability in end-up utilization. Importantly, it was found that the presence of PAL in the films provided enhanced mechanical properties, whereas CS, GA and ZnO supplied a broad-spectrum antibacterial activity, especially for drug-resistant bacteria such as ESBL—<i>E. coli</i> and MRSA. Overall, this research demonstrated that the prepared films can be a promising candidate for wound-care materials.
format	article
author	Qian Zhang Hong Zhang Aiping Hui Junjie Ding Xinyue Liu Aiqin Wang
author_facet	Qian Zhang Hong Zhang Aiping Hui Junjie Ding Xinyue Liu Aiqin Wang
author_sort	Qian Zhang
title	Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
title_short	Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
title_full	Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
title_fullStr	Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
title_full_unstemmed	Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing
title_sort	synergistic effect of glycyrrhizic acid and zno/palygorskite on improving chitosan-based films and their potential application in wound healing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/acc304183f7041e19697afd4ff6c99a3
work_keys_str_mv	AT qianzhang synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing AT hongzhang synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing AT aipinghui synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing AT junjieding synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing AT xinyueliu synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing AT aiqinwang synergisticeffectofglycyrrhizicacidandznopalygorskiteonimprovingchitosanbasedfilmsandtheirpotentialapplicationinwoundhealing
_version_	1718410733788594176

Synergistic Effect of Glycyrrhizic Acid and ZnO/Palygorskite on Improving Chitosan-Based Films and Their Potential Application in Wound Healing

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