Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review

Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indometh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Pacifici GM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/acc7bd508b4544d4b9ab4538559aea70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:acc7bd508b4544d4b9ab4538559aea70
record_format	dspace
spelling	oai:doaj.org-article:acc7bd508b4544d4b9ab4538559aea702021-12-02T07:24:22ZDifferential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review1179-1438https://doaj.org/article/acc7bd508b4544d4b9ab4538559aea702014-07-01T00:00:00Zhttp://www.dovepress.com/differential-renal-adverse-effects-of-ibuprofen-and-indomethacin-in-pr-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438 Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. Methods: The following three parameters of renal function were taken into consideration: 1) the urine output; 2) the serum creatinine concentration; and 3) the frequency of oliguria. The bibliographic search was performed using PubMed and Embase databases as search engines. Results: Urine output ranged from 3.5±1.2 to 4.0±1.4 mL/kg/h after ibuprofen treatment, and from 2.8±1.1 to 3.6±1.4 mL/kg/h after indomethacin treatment. The values for ibuprofen are significantly (P<0.05) higher than those for indomethacin. The serum creatinine concentrations ranged from 0.98±0.24 to 1.48±0.2 mg/dL after ibuprofen treatment, and from 1.06±0.24 and 2.03±2.10 mg/dL after indomethacin treatment. The values for ibuprofen are significantly (P<0.05) lower than those for indomethacin. The frequency of oliguria ranged from 1.0% to 9.6% (ibuprofen) and from 14.8% to 40.0% (indomethacin), and was significantly lower following ibuprofen than indomethacin administration. In infants with body weight lower than 1,000 g, oliguria appeared in 5% (ibuprofen) and 40% (indomethacin; P=0.02). Conclusion: Indomethacin is associated with more severe renal adverse effects than ibuprofen. Ibuprofen is less nephrotoxic than indomethacin and should be used to treat patent ductus arteriosus in preterm infants. Immaturity increases the frequency of adverse effects of indomethacin. Keywords: ibuprofen, indomethacin, patent-ductus-arteriosus, renal-side-effectsPacifici GMDove Medical PressarticleTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol 2014, Iss default, Pp 111-116 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Pacifici GM Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
description	Gian Maria Pacifici Medical School, Department of Translational Research and New Technologies in Medicine and Surgery, Section of Pharmacology, University of Pisa, Pisa, Italy Objective: The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. Methods: The following three parameters of renal function were taken into consideration: 1) the urine output; 2) the serum creatinine concentration; and 3) the frequency of oliguria. The bibliographic search was performed using PubMed and Embase databases as search engines. Results: Urine output ranged from 3.5±1.2 to 4.0±1.4 mL/kg/h after ibuprofen treatment, and from 2.8±1.1 to 3.6±1.4 mL/kg/h after indomethacin treatment. The values for ibuprofen are significantly (P<0.05) higher than those for indomethacin. The serum creatinine concentrations ranged from 0.98±0.24 to 1.48±0.2 mg/dL after ibuprofen treatment, and from 1.06±0.24 and 2.03±2.10 mg/dL after indomethacin treatment. The values for ibuprofen are significantly (P<0.05) lower than those for indomethacin. The frequency of oliguria ranged from 1.0% to 9.6% (ibuprofen) and from 14.8% to 40.0% (indomethacin), and was significantly lower following ibuprofen than indomethacin administration. In infants with body weight lower than 1,000 g, oliguria appeared in 5% (ibuprofen) and 40% (indomethacin; P=0.02). Conclusion: Indomethacin is associated with more severe renal adverse effects than ibuprofen. Ibuprofen is less nephrotoxic than indomethacin and should be used to treat patent ductus arteriosus in preterm infants. Immaturity increases the frequency of adverse effects of indomethacin. Keywords: ibuprofen, indomethacin, patent-ductus-arteriosus, renal-side-effects
format	article
author	Pacifici GM
author_facet	Pacifici GM
author_sort	Pacifici GM
title	Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
title_short	Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
title_full	Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
title_fullStr	Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
title_full_unstemmed	Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
title_sort	differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/acc7bd508b4544d4b9ab4538559aea70
work_keys_str_mv	AT pacificigm differentialrenaladverseeffectsofibuprofenandindomethacininpreterminfantsareview
_version_	1718399471511928832

Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review

Ejemplares similares