Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.

A firm connection of the bone-implant-fixation system is of utmost importance for patients with cranial defects. In order to improve the connection reliability, the current research focuses on finding the optimal fixation method, as well as selection of the implant manufacturing methods and the used...

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Autores principales:	Jakub Chamrad, Petr Marcián, Jan Cizek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acc7cd9f22184a9a986399c53cd1c25e
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spelling	oai:doaj.org-article:acc7cd9f22184a9a986399c53cd1c25e2021-12-02T20:06:50ZBeneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.1932-620310.1371/journal.pone.0254837https://doaj.org/article/acc7cd9f22184a9a986399c53cd1c25e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254837https://doaj.org/toc/1932-6203A firm connection of the bone-implant-fixation system is of utmost importance for patients with cranial defects. In order to improve the connection reliability, the current research focuses on finding the optimal fixation method, as well as selection of the implant manufacturing methods and the used materials. For the latter, implementation of bioactive materials such as hydroxyapatite or other calcium phosphates has also been considered in the literature. The aim of this study was to investigate the effect of gradual osseointegration on the biomechanical performance of cranial Ti6Al4V implants with a deposited HA coating as the osseointegration agent. This effect was assessed by two different computational approaches using finite element method (FEM) modeling. The values of key input parameters necessary for FEM were obtained from experimental plasma spray deposition of HA layers onto Ti6Al4V samples. Immediately upon implantation, the HA layer at the bone-implant contact area brought only a slight decrease in the values of von Mises stress in the implant and the micro-screws when compared to a non-coated counterpart; importantly, this was without any negative trade-off in other important characteristics. The major benefit of the HA coatings was manifested upon the modeled osseointegration: the results of both approaches confirmed a significant reduction of investigated parameters such as the total implant displacements (reduced from 0.050 mm to 0.012 mm and 0.002 mm while using Approach I and II, respectively) and stresses (reduced from 52 MPa to 10 MPa and 1 MPa) in the implanted components in comparison to non-coated variant. This is a very promising result for potential use of thermally sprayed HA coatings for cranial implants.Jakub ChamradPetr MarciánJan CizekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254837 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jakub Chamrad Petr Marcián Jan Cizek Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
description	A firm connection of the bone-implant-fixation system is of utmost importance for patients with cranial defects. In order to improve the connection reliability, the current research focuses on finding the optimal fixation method, as well as selection of the implant manufacturing methods and the used materials. For the latter, implementation of bioactive materials such as hydroxyapatite or other calcium phosphates has also been considered in the literature. The aim of this study was to investigate the effect of gradual osseointegration on the biomechanical performance of cranial Ti6Al4V implants with a deposited HA coating as the osseointegration agent. This effect was assessed by two different computational approaches using finite element method (FEM) modeling. The values of key input parameters necessary for FEM were obtained from experimental plasma spray deposition of HA layers onto Ti6Al4V samples. Immediately upon implantation, the HA layer at the bone-implant contact area brought only a slight decrease in the values of von Mises stress in the implant and the micro-screws when compared to a non-coated counterpart; importantly, this was without any negative trade-off in other important characteristics. The major benefit of the HA coatings was manifested upon the modeled osseointegration: the results of both approaches confirmed a significant reduction of investigated parameters such as the total implant displacements (reduced from 0.050 mm to 0.012 mm and 0.002 mm while using Approach I and II, respectively) and stresses (reduced from 52 MPa to 10 MPa and 1 MPa) in the implanted components in comparison to non-coated variant. This is a very promising result for potential use of thermally sprayed HA coatings for cranial implants.
format	article
author	Jakub Chamrad Petr Marcián Jan Cizek
author_facet	Jakub Chamrad Petr Marcián Jan Cizek
author_sort	Jakub Chamrad
title	Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
title_short	Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
title_full	Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
title_fullStr	Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
title_full_unstemmed	Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.
title_sort	beneficial osseointegration effect of hydroxyapatite coating on cranial implant - fem investigation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/acc7cd9f22184a9a986399c53cd1c25e
work_keys_str_mv	AT jakubchamrad beneficialosseointegrationeffectofhydroxyapatitecoatingoncranialimplantfeminvestigation AT petrmarcian beneficialosseointegrationeffectofhydroxyapatitecoatingoncranialimplantfeminvestigation AT jancizek beneficialosseointegrationeffectofhydroxyapatitecoatingoncranialimplantfeminvestigation
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Beneficial osseointegration effect of hydroxyapatite coating on cranial implant - FEM investigation.

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