Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period

The problem of preventing the development of metabolic disorders in the early postanesthesia period is relevant in modern anesthesiology and pharmacology. This article is devoted to pharmacological correction of energy metabolism in the liver and brain of white rats by phytoremedy «Polynoophyt» in t...

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Autores principales:	A. A. Toropova, M. Y. Itygilov, Y. G. Razuvaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	plant remedy «polynoophyt» early postanesthesia period sodium thiopental energy metabolism lactate pyruvate atp Science Q
Acceso en línea:	https://doaj.org/article/accb356294834ad58ecc2cedbb49c6e4
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spelling	oai:doaj.org-article:accb356294834ad58ecc2cedbb49c6e42021-11-23T06:14:32ZEffect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period2541-94202587-9596https://doaj.org/article/accb356294834ad58ecc2cedbb49c6e42015-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/41https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The problem of preventing the development of metabolic disorders in the early postanesthesia period is relevant in modern anesthesiology and pharmacology. This article is devoted to pharmacological correction of energy metabolism in the liver and brain of white rats by phytoremedy «Polynoophyt» in the early postanesthesia period after application of sodium thiopental. The experiments were performed on 33 white Wistar rats. The content ATP as the main macroergic component and energy-supply metabolites (lactate and pyruvate) was determined. It shown that the course administration of «Polynoophyt» resulted to rising of ATP content in the liver and brain at 68% (p < 0,05) and 54% (p < 0,05) compared with the control, respectively. Furthermore, the ratio of lactate/pyruvate decreased indicating the normalization of the intensity of glycolytic and oxidative transformation of carbohydrates into the liver and brain. It should be emphasized that the phytoremedy «Polynoophyt» reduced the concentration of lactate in the liver and brain in 2,5 and 1,6 times respectively. The pyruvate content in brain increased at 45% (p < 0,05) accelerating the ATP resynthesis. The effect of energy-supply improvement was caused by the presence of a complex of biologically active substances (flavonoids, tannins, polysaccharides etc.) providing a wide range of pharmacological actions.A. A. ToropovaM. Y. ItygilovY. G. RazuvaevaScientific Сentre for Family Health and Human Reproduction Problemsarticleplant remedy «polynoophyt»early postanesthesia periodsodium thiopentalenergy metabolismlactatepyruvateatpScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2, Pp 95-98 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	plant remedy «polynoophyt» early postanesthesia period sodium thiopental energy metabolism lactate pyruvate atp Science Q
spellingShingle	plant remedy «polynoophyt» early postanesthesia period sodium thiopental energy metabolism lactate pyruvate atp Science Q A. A. Toropova M. Y. Itygilov Y. G. Razuvaeva Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
description	The problem of preventing the development of metabolic disorders in the early postanesthesia period is relevant in modern anesthesiology and pharmacology. This article is devoted to pharmacological correction of energy metabolism in the liver and brain of white rats by phytoremedy «Polynoophyt» in the early postanesthesia period after application of sodium thiopental. The experiments were performed on 33 white Wistar rats. The content ATP as the main macroergic component and energy-supply metabolites (lactate and pyruvate) was determined. It shown that the course administration of «Polynoophyt» resulted to rising of ATP content in the liver and brain at 68% (p < 0,05) and 54% (p < 0,05) compared with the control, respectively. Furthermore, the ratio of lactate/pyruvate decreased indicating the normalization of the intensity of glycolytic and oxidative transformation of carbohydrates into the liver and brain. It should be emphasized that the phytoremedy «Polynoophyt» reduced the concentration of lactate in the liver and brain in 2,5 and 1,6 times respectively. The pyruvate content in brain increased at 45% (p < 0,05) accelerating the ATP resynthesis. The effect of energy-supply improvement was caused by the presence of a complex of biologically active substances (flavonoids, tannins, polysaccharides etc.) providing a wide range of pharmacological actions.
format	article
author	A. A. Toropova M. Y. Itygilov Y. G. Razuvaeva
author_facet	A. A. Toropova M. Y. Itygilov Y. G. Razuvaeva
author_sort	A. A. Toropova
title	Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
title_short	Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
title_full	Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
title_fullStr	Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
title_full_unstemmed	Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period
title_sort	effect of plant remedy «polynoophyt» on energy metabolism of white rats in the early postanesthesia period
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/accb356294834ad58ecc2cedbb49c6e4
work_keys_str_mv	AT aatoropova effectofplantremedypolynoophytonenergymetabolismofwhiteratsintheearlypostanesthesiaperiod AT myitygilov effectofplantremedypolynoophytonenergymetabolismofwhiteratsintheearlypostanesthesiaperiod AT ygrazuvaeva effectofplantremedypolynoophytonenergymetabolismofwhiteratsintheearlypostanesthesiaperiod
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Effect of plant remedy «Polynoophyt» on energy metabolism of white rats in the early postanesthesia period

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