Strategies for improving early detection of glaucoma: the combined structure–function index

Strategies for improving early detection of glaucoma: the combined structure–function index

Andrew J Tatham, Robert N Weinreb, Felipe A MedeirosHamilton Glaucoma Center, Department of Ophthalmology, University of California, La Jolla, CA, USAAbstract: The early detection of glaucoma is important in order to enable appropriate monitoring and treatment, and to minimize the risk of irreversi...

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Autores principales: Tatham AJ, Weinreb RN, Medeiros FA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/acd00541ecc449bb93d3e99af24847e3
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spelling oai:doaj.org-article:acd00541ecc449bb93d3e99af24847e32021-12-02T06:18:36ZStrategies for improving early detection of glaucoma: the combined structure–function index1177-5483https://doaj.org/article/acd00541ecc449bb93d3e99af24847e32014-03-01T00:00:00Zhttp://www.dovepress.com/strategies-for-improving-early-detection-of-glaucoma-the-combined-stru-a16241https://doaj.org/toc/1177-5483 Andrew J Tatham, Robert N Weinreb, Felipe A MedeirosHamilton Glaucoma Center, Department of Ophthalmology, University of California, La Jolla, CA, USAAbstract: The early detection of glaucoma is important in order to enable appropriate monitoring and treatment, and to minimize the risk of irreversible visual field loss. Although advances in ocular imaging offer the potential for earlier diagnosis, the best method is likely to involve a combination of information from structural and functional tests. Recent studies have shown it is possible to estimate the number of retinal ganglion cells from optical coherence tomography and standard automated perimetry, and to then pool the results to produce a combined structure–function index (CSFI). The CSFI represents the estimated percentage of retinal ganglion cells lost compared to an age-matched healthy eye. Previous studies have suggested that the CSFI is better able to detect glaucoma than isolated measures of structure and function, and that it performs well even in preperimetric glaucoma. The purpose of this review is to describe new strategies, such as the CSFI, that have the potential to improve the early detection of glaucoma. We also describe how our ability to detect early glaucoma may be further enhanced by incorporating demographic risk factors, clinical examination findings, and imaging and functional test results into intuitive models that provide estimates of disease probability.Keywords: glaucoma, optical coherence tomography, OCT, perimetry, spectral domain, retinal ganglion cellsTatham AJWeinreb RNMedeiros FADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 611-621 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Tatham AJ
Weinreb RN
Medeiros FA
Strategies for improving early detection of glaucoma: the combined structure–function index
description Andrew J Tatham, Robert N Weinreb, Felipe A MedeirosHamilton Glaucoma Center, Department of Ophthalmology, University of California, La Jolla, CA, USAAbstract: The early detection of glaucoma is important in order to enable appropriate monitoring and treatment, and to minimize the risk of irreversible visual field loss. Although advances in ocular imaging offer the potential for earlier diagnosis, the best method is likely to involve a combination of information from structural and functional tests. Recent studies have shown it is possible to estimate the number of retinal ganglion cells from optical coherence tomography and standard automated perimetry, and to then pool the results to produce a combined structure–function index (CSFI). The CSFI represents the estimated percentage of retinal ganglion cells lost compared to an age-matched healthy eye. Previous studies have suggested that the CSFI is better able to detect glaucoma than isolated measures of structure and function, and that it performs well even in preperimetric glaucoma. The purpose of this review is to describe new strategies, such as the CSFI, that have the potential to improve the early detection of glaucoma. We also describe how our ability to detect early glaucoma may be further enhanced by incorporating demographic risk factors, clinical examination findings, and imaging and functional test results into intuitive models that provide estimates of disease probability.Keywords: glaucoma, optical coherence tomography, OCT, perimetry, spectral domain, retinal ganglion cells
format article
author Tatham AJ
Weinreb RN
Medeiros FA
author_facet Tatham AJ
Weinreb RN
Medeiros FA
author_sort Tatham AJ
title Strategies for improving early detection of glaucoma: the combined structure–function index
title_short Strategies for improving early detection of glaucoma: the combined structure–function index
title_full Strategies for improving early detection of glaucoma: the combined structure–function index
title_fullStr Strategies for improving early detection of glaucoma: the combined structure–function index
title_full_unstemmed Strategies for improving early detection of glaucoma: the combined structure–function index
title_sort strategies for improving early detection of glaucoma: the combined structure–function index
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/acd00541ecc449bb93d3e99af24847e3
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AT medeirosfa strategiesforimprovingearlydetectionofglaucomathecombinedstructurendashfunctionindex
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