The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.

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Autores principales:	Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2
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spelling	oai:doaj.org-article:acd1f474dbe44e05886bd6aede2b54b22021-11-21T12:34:03ZThe APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages10.1038/s41467-021-26987-12041-1723https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26987-1https://doaj.org/toc/2041-1723Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.Kelvin Ka Lok WuKeKao LongHuige LinParco Ming Fai SiuRuby Lai Chong HooDewei YeAimin XuKenneth King Yip ChengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kelvin Ka Lok Wu KeKao Long Huige Lin Parco Ming Fai Siu Ruby Lai Chong Hoo Dewei Ye Aimin Xu Kenneth King Yip Cheng The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
description	Inflammasome regulation is not fully understood. Here the authors show that the early endosomal APPL1-Rab5 axis removes damaged mitochondria and then restricts the inflammasome response in macrophages, alleviating the inflammatory diseases.
format	article
author	Kelvin Ka Lok Wu KeKao Long Huige Lin Parco Ming Fai Siu Ruby Lai Chong Hoo Dewei Ye Aimin Xu Kenneth King Yip Cheng
author_facet	Kelvin Ka Lok Wu KeKao Long Huige Lin Parco Ming Fai Siu Ruby Lai Chong Hoo Dewei Ye Aimin Xu Kenneth King Yip Cheng
author_sort	Kelvin Ka Lok Wu
title	The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
title_short	The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
title_full	The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
title_fullStr	The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
title_full_unstemmed	The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
title_sort	appl1-rab5 axis restricts nlrp3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2
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The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages

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