Assessment of protein–protein interfaces in cryo-EM derived assemblies

Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–protein interfaces in more than 1000 PDB-deposited cryo-E...

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Autores principales:	Sony Malhotra, Agnel Praveen Joseph, Jeyan Thiyagalingam, Maya Topf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e269
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id	oai:doaj.org-article:acd3b58ac1e54f71ae0b83863127e269
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spelling	oai:doaj.org-article:acd3b58ac1e54f71ae0b83863127e2692021-12-02T17:52:38ZAssessment of protein–protein interfaces in cryo-EM derived assemblies10.1038/s41467-021-23692-x2041-1723https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e2692021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23692-xhttps://doaj.org/toc/2041-1723Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–protein interfaces in more than 1000 PDB-deposited cryo-EM structures and show that it can be used as a complementary assessment tool for cryo-EM model validation.Sony MalhotraAgnel Praveen JosephJeyan ThiyagalingamMaya TopfNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sony Malhotra Agnel Praveen Joseph Jeyan Thiyagalingam Maya Topf Assessment of protein–protein interfaces in cryo-EM derived assemblies
description	Here, the authors present Protein Interface-score (PI-score), a machine learning-based metric that has been trained on protein–protein interfaces’ features from high-resolution crystal structures. They use the PI-score to evaluate the protein–protein interfaces in more than 1000 PDB-deposited cryo-EM structures and show that it can be used as a complementary assessment tool for cryo-EM model validation.
format	article
author	Sony Malhotra Agnel Praveen Joseph Jeyan Thiyagalingam Maya Topf
author_facet	Sony Malhotra Agnel Praveen Joseph Jeyan Thiyagalingam Maya Topf
author_sort	Sony Malhotra
title	Assessment of protein–protein interfaces in cryo-EM derived assemblies
title_short	Assessment of protein–protein interfaces in cryo-EM derived assemblies
title_full	Assessment of protein–protein interfaces in cryo-EM derived assemblies
title_fullStr	Assessment of protein–protein interfaces in cryo-EM derived assemblies
title_full_unstemmed	Assessment of protein–protein interfaces in cryo-EM derived assemblies
title_sort	assessment of protein–protein interfaces in cryo-em derived assemblies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acd3b58ac1e54f71ae0b83863127e269
work_keys_str_mv	AT sonymalhotra assessmentofproteinproteininterfacesincryoemderivedassemblies AT agnelpraveenjoseph assessmentofproteinproteininterfacesincryoemderivedassemblies AT jeyanthiyagalingam assessmentofproteinproteininterfacesincryoemderivedassemblies AT mayatopf assessmentofproteinproteininterfacesincryoemderivedassemblies
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Assessment of protein–protein interfaces in cryo-EM derived assemblies

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