Risk score to stratify miscarriage risk levels in preconception women

Abstract Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited....

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Autores principales:	Xin Hui Choo, Chee Wai Ku, Yin Bun Cheung, Keith M. Godfrey, Yap-Seng Chong, Lynette Pei-Chi Shek, Kok Hian Tan, Thiam Chye Tan, Sadhana Nadarajah, Fabian Kok Peng Yap, Marjorelee T. Colega, Mary Foong-Fong Chong, Shiao-Yng Chan, See Ling Loy, Jerry Kok Yen Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acd48f21f0944899b5541f6d2cdbee0f
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spelling	oai:doaj.org-article:acd48f21f0944899b5541f6d2cdbee0f2021-12-02T14:59:29ZRisk score to stratify miscarriage risk levels in preconception women10.1038/s41598-021-91567-82045-2322https://doaj.org/article/acd48f21f0944899b5541f6d2cdbee0f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91567-8https://doaj.org/toc/2045-2322Abstract Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.Xin Hui ChooChee Wai KuYin Bun CheungKeith M. GodfreyYap-Seng ChongLynette Pei-Chi ShekKok Hian TanThiam Chye TanSadhana NadarajahFabian Kok Peng YapMarjorelee T. ColegaMary Foong-Fong ChongShiao-Yng ChanSee Ling LoyJerry Kok Yen ChanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Hui Choo Chee Wai Ku Yin Bun Cheung Keith M. Godfrey Yap-Seng Chong Lynette Pei-Chi Shek Kok Hian Tan Thiam Chye Tan Sadhana Nadarajah Fabian Kok Peng Yap Marjorelee T. Colega Mary Foong-Fong Chong Shiao-Yng Chan See Ling Loy Jerry Kok Yen Chan Risk score to stratify miscarriage risk levels in preconception women
description	Abstract Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.
format	article
author	Xin Hui Choo Chee Wai Ku Yin Bun Cheung Keith M. Godfrey Yap-Seng Chong Lynette Pei-Chi Shek Kok Hian Tan Thiam Chye Tan Sadhana Nadarajah Fabian Kok Peng Yap Marjorelee T. Colega Mary Foong-Fong Chong Shiao-Yng Chan See Ling Loy Jerry Kok Yen Chan
author_facet	Xin Hui Choo Chee Wai Ku Yin Bun Cheung Keith M. Godfrey Yap-Seng Chong Lynette Pei-Chi Shek Kok Hian Tan Thiam Chye Tan Sadhana Nadarajah Fabian Kok Peng Yap Marjorelee T. Colega Mary Foong-Fong Chong Shiao-Yng Chan See Ling Loy Jerry Kok Yen Chan
author_sort	Xin Hui Choo
title	Risk score to stratify miscarriage risk levels in preconception women
title_short	Risk score to stratify miscarriage risk levels in preconception women
title_full	Risk score to stratify miscarriage risk levels in preconception women
title_fullStr	Risk score to stratify miscarriage risk levels in preconception women
title_full_unstemmed	Risk score to stratify miscarriage risk levels in preconception women
title_sort	risk score to stratify miscarriage risk levels in preconception women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acd48f21f0944899b5541f6d2cdbee0f
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Risk score to stratify miscarriage risk levels in preconception women

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