Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.

Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.

Tuberous sclerosis complex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epilepsy. Heightened signaling through the mammalian target of rapamycin (mTOR) pathway is involved in TSC pathology, however it remains unclear how other signaling...

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Autores principales: Wyatt B Potter, Trina Basu, Kenneth J O'Riordan, Allison Kirchner, Paul Rutecki, Corinna Burger, Avtar Roopra
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/acd6306d86874cb3b4e33308045d9d42
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