Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour...
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Nature Portfolio
2017
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oai:doaj.org-article:acd6edf30f5b42e78199d6bb93f923c92021-12-02T17:01:24ZTumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis10.1038/s41467-017-00678-22041-1723https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c92017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00678-2https://doaj.org/toc/2041-1723Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth.Sara TrabanelliMathieu F. ChevalierAmaia Martinez-UsatorreAlejandra Gomez-CadenaBérengère SaloméMariangela LeccisoValentina SalvestriniGrégory VerdeilJulien RacleCristina PapayannidisHideaki MoritaIrene PizzitolaCamille GrandclémentPerrine BohnerElena BruniMukul GirotraRani PallaviPaolo FalvoElisabeth Oppliger LeibundgutGabriela M. BaerlocherCarmelo Carlo-StellaDaniela TaurinoArmando SantoroOrietta SpinelliAlessandro RambaldiEmanuela GiarinGiuseppe BassoCristina TresoldiFabio CiceriDavid GfellerCezmi A. AkdisLuca MazzarellaSaverio MinucciPier Giuseppe PelicciEmanuela MarcenaroAndrew N. J. McKenzieDominique VanheckeGeorge CoukosDomenico MavilioAntonio CurtiLaurent DerréCamilla JandusNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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DOAJ |
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EN |
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Science Q |
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Science Q Sara Trabanelli Mathieu F. Chevalier Amaia Martinez-Usatorre Alejandra Gomez-Cadena Bérengère Salomé Mariangela Lecciso Valentina Salvestrini Grégory Verdeil Julien Racle Cristina Papayannidis Hideaki Morita Irene Pizzitola Camille Grandclément Perrine Bohner Elena Bruni Mukul Girotra Rani Pallavi Paolo Falvo Elisabeth Oppliger Leibundgut Gabriela M. Baerlocher Carmelo Carlo-Stella Daniela Taurino Armando Santoro Orietta Spinelli Alessandro Rambaldi Emanuela Giarin Giuseppe Basso Cristina Tresoldi Fabio Ciceri David Gfeller Cezmi A. Akdis Luca Mazzarella Saverio Minucci Pier Giuseppe Pelicci Emanuela Marcenaro Andrew N. J. McKenzie Dominique Vanhecke George Coukos Domenico Mavilio Antonio Curti Laurent Derré Camilla Jandus Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| description |
Group 2 innate lymphoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunity is still unclear. Here the authors show that, in acute promyelocytic leukaemia, tumour-activated ILC2s secrete IL-13 to induce myeloid-derived suppressor cells and support tumour growth. |
| format |
article |
| author |
Sara Trabanelli Mathieu F. Chevalier Amaia Martinez-Usatorre Alejandra Gomez-Cadena Bérengère Salomé Mariangela Lecciso Valentina Salvestrini Grégory Verdeil Julien Racle Cristina Papayannidis Hideaki Morita Irene Pizzitola Camille Grandclément Perrine Bohner Elena Bruni Mukul Girotra Rani Pallavi Paolo Falvo Elisabeth Oppliger Leibundgut Gabriela M. Baerlocher Carmelo Carlo-Stella Daniela Taurino Armando Santoro Orietta Spinelli Alessandro Rambaldi Emanuela Giarin Giuseppe Basso Cristina Tresoldi Fabio Ciceri David Gfeller Cezmi A. Akdis Luca Mazzarella Saverio Minucci Pier Giuseppe Pelicci Emanuela Marcenaro Andrew N. J. McKenzie Dominique Vanhecke George Coukos Domenico Mavilio Antonio Curti Laurent Derré Camilla Jandus |
| author_facet |
Sara Trabanelli Mathieu F. Chevalier Amaia Martinez-Usatorre Alejandra Gomez-Cadena Bérengère Salomé Mariangela Lecciso Valentina Salvestrini Grégory Verdeil Julien Racle Cristina Papayannidis Hideaki Morita Irene Pizzitola Camille Grandclément Perrine Bohner Elena Bruni Mukul Girotra Rani Pallavi Paolo Falvo Elisabeth Oppliger Leibundgut Gabriela M. Baerlocher Carmelo Carlo-Stella Daniela Taurino Armando Santoro Orietta Spinelli Alessandro Rambaldi Emanuela Giarin Giuseppe Basso Cristina Tresoldi Fabio Ciceri David Gfeller Cezmi A. Akdis Luca Mazzarella Saverio Minucci Pier Giuseppe Pelicci Emanuela Marcenaro Andrew N. J. McKenzie Dominique Vanhecke George Coukos Domenico Mavilio Antonio Curti Laurent Derré Camilla Jandus |
| author_sort |
Sara Trabanelli |
| title |
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| title_short |
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| title_full |
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| title_fullStr |
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| title_full_unstemmed |
Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis |
| title_sort |
tumour-derived pgd2 and nkp30-b7h6 engagement drives an immunosuppressive ilc2-mdsc axis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/acd6edf30f5b42e78199d6bb93f923c9 |
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