Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66

Qian Xu1, Hongyan Lu1, Jingchao Zhang1, Guoyu Lu2, Zhennan Deng2, Anchun Mo31State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R. China; 2Research Center for Nano-Biomaterials, Sichuan University, Chengdu, 610064, P.R. China; 3Department of Oral Implant, West China Colleg...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Xu, Hongyan Lu, Jingchao Zhang, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/acd8522f242e4ecc91084b1a2a1dd3e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:acd8522f242e4ecc91084b1a2a1dd3e1
record_format	dspace
spelling	oai:doaj.org-article:acd8522f242e4ecc91084b1a2a1dd3e12021-12-02T04:19:56ZTissue engineering scaffold material of porous nanohydroxyapatite/polyamide 661176-91141178-2013https://doaj.org/article/acd8522f242e4ecc91084b1a2a1dd3e12010-04-01T00:00:00Zhttp://www.dovepress.com/tissue-engineering-scaffold-material-of-porous-nanohydroxyapatitepolya-a4284https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qian Xu1, Hongyan Lu1, Jingchao Zhang1, Guoyu Lu2, Zhennan Deng2, Anchun Mo31State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R. China; 2Research Center for Nano-Biomaterials, Sichuan University, Chengdu, 610064, P.R. China; 3Department of Oral Implant, West China College of Stomatology, Sichuan University, Chengdu, 610041, P.R. ChinaAbstract: The aim of the study was to investigate a porous nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold material that was implanted into muscle and tibiae of 16 New Zealand white rabbits to evaluate the biocompatibility and osteogenesis and osteoinductivity of the materials in vivo. The samples were harvested at 2, 4, 12 and 26 weeks respectively, and subjected to histological analysis. At 2 weeks, the experiment showed that osteogenesis was detected in porous n-HA/PA66 composite and the density of new bone formation was similar to the surrounding host bone at 12 weeks. The study indicated that three-dimensional pore structures could facilitate cell adhesion, differentiation and proliferation, and help with fibrovascular and nerve colonization. In conclusion, porous n-HA/PA66 scaffold material could be a good candidate as a bone substitute material used in clinics due to its excellent histocompatibility, osteoconductivity and osteoinductivity.Keywords: porous, nano hydroxyapatite, polyamide, interconnected porosity, biocompatibility, osteoconductivity, osteoinductivity Qian XuHongyan LuJingchao Zhanget alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 331-335 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Qian Xu Hongyan Lu Jingchao Zhang et al Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
description	Qian Xu1, Hongyan Lu1, Jingchao Zhang1, Guoyu Lu2, Zhennan Deng2, Anchun Mo31State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R. China; 2Research Center for Nano-Biomaterials, Sichuan University, Chengdu, 610064, P.R. China; 3Department of Oral Implant, West China College of Stomatology, Sichuan University, Chengdu, 610041, P.R. ChinaAbstract: The aim of the study was to investigate a porous nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold material that was implanted into muscle and tibiae of 16 New Zealand white rabbits to evaluate the biocompatibility and osteogenesis and osteoinductivity of the materials in vivo. The samples were harvested at 2, 4, 12 and 26 weeks respectively, and subjected to histological analysis. At 2 weeks, the experiment showed that osteogenesis was detected in porous n-HA/PA66 composite and the density of new bone formation was similar to the surrounding host bone at 12 weeks. The study indicated that three-dimensional pore structures could facilitate cell adhesion, differentiation and proliferation, and help with fibrovascular and nerve colonization. In conclusion, porous n-HA/PA66 scaffold material could be a good candidate as a bone substitute material used in clinics due to its excellent histocompatibility, osteoconductivity and osteoinductivity.Keywords: porous, nano hydroxyapatite, polyamide, interconnected porosity, biocompatibility, osteoconductivity, osteoinductivity
format	article
author	Qian Xu Hongyan Lu Jingchao Zhang et al
author_facet	Qian Xu Hongyan Lu Jingchao Zhang et al
author_sort	Qian Xu
title	Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
title_short	Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
title_full	Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
title_fullStr	Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
title_full_unstemmed	Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
title_sort	tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/acd8522f242e4ecc91084b1a2a1dd3e1
work_keys_str_mv	AT qianxu tissueengineeringscaffoldmaterialofporousnanohydroxyapatitepolyamide66 AT hongyanlu tissueengineeringscaffoldmaterialofporousnanohydroxyapatitepolyamide66 AT jingchaozhang tissueengineeringscaffoldmaterialofporousnanohydroxyapatitepolyamide66 AT etal tissueengineeringscaffoldmaterialofporousnanohydroxyapatitepolyamide66
_version_	1718401327443214336

Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66

Ejemplares similares