Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber

Abstract Animal gut harbors diverse microbes that play crucial roles in the nutrition uptake, metabolism, and the regulation of host immune responses. The intestinal microbiota homeostasis is critical for health but poorly understood. Probiotics Paracoccus marcusii DB11 and Bacillus cereus G19, and...

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Autores principales:	Gang Yang, Mo Peng, Xiangli Tian, Shuanglin Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acd885cb1aba461997b667cdeceab94f
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spelling	oai:doaj.org-article:acd885cb1aba461997b667cdeceab94f2021-12-02T16:06:58ZMolecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber10.1038/s41598-017-05312-12045-2322https://doaj.org/article/acd885cb1aba461997b667cdeceab94f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05312-1https://doaj.org/toc/2045-2322Abstract Animal gut harbors diverse microbes that play crucial roles in the nutrition uptake, metabolism, and the regulation of host immune responses. The intestinal microbiota homeostasis is critical for health but poorly understood. Probiotics Paracoccus marcusii DB11 and Bacillus cereus G19, and antibiotics florfenicol did not significantly impact species richness and the diversity of intestinal microbiota of sea cucumber, in comparison with those in the control group by high-throughput sequencing. Molecular ecological network analysis indicated that P. marcusii DB11 supplementation may lead to sub-module integration and the formation of a large, new sub-module, and enhance species-species interactions and connecter and module hub numbers. B. cereus G19 supplementation decreased sub-module numbers, and increased the number of species-species interactions and module hubs. Sea cucumber treated with florfenicol were shown to have only one connecter and the lowest number of operational taxonomic units (OTUs) and species-species interactions within the ecological network. These results suggested that P. marcusii DB11 or B. cereus G19 may promote intestinal microbiota homeostasis by improving modularity, enhancing species-species interactions and increasing the number of connecters and/or module hubs within the network. In contrast, the use of florfenicol can lead to homeostatic collapse through the deterioration of the ecological network.Gang YangMo PengXiangli TianShuanglin DongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gang Yang Mo Peng Xiangli Tian Shuanglin Dong Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
description	Abstract Animal gut harbors diverse microbes that play crucial roles in the nutrition uptake, metabolism, and the regulation of host immune responses. The intestinal microbiota homeostasis is critical for health but poorly understood. Probiotics Paracoccus marcusii DB11 and Bacillus cereus G19, and antibiotics florfenicol did not significantly impact species richness and the diversity of intestinal microbiota of sea cucumber, in comparison with those in the control group by high-throughput sequencing. Molecular ecological network analysis indicated that P. marcusii DB11 supplementation may lead to sub-module integration and the formation of a large, new sub-module, and enhance species-species interactions and connecter and module hub numbers. B. cereus G19 supplementation decreased sub-module numbers, and increased the number of species-species interactions and module hubs. Sea cucumber treated with florfenicol were shown to have only one connecter and the lowest number of operational taxonomic units (OTUs) and species-species interactions within the ecological network. These results suggested that P. marcusii DB11 or B. cereus G19 may promote intestinal microbiota homeostasis by improving modularity, enhancing species-species interactions and increasing the number of connecters and/or module hubs within the network. In contrast, the use of florfenicol can lead to homeostatic collapse through the deterioration of the ecological network.
format	article
author	Gang Yang Mo Peng Xiangli Tian Shuanglin Dong
author_facet	Gang Yang Mo Peng Xiangli Tian Shuanglin Dong
author_sort	Gang Yang
title	Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
title_short	Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
title_full	Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
title_fullStr	Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
title_full_unstemmed	Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber
title_sort	molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: an example of sea cucumber
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/acd885cb1aba461997b667cdeceab94f
work_keys_str_mv	AT gangyang molecularecologicalnetworkanalysisrevealstheeffectsofprobioticsandflorfenicolonintestinalmicrobiotahomeostasisanexampleofseacucumber AT mopeng molecularecologicalnetworkanalysisrevealstheeffectsofprobioticsandflorfenicolonintestinalmicrobiotahomeostasisanexampleofseacucumber AT xianglitian molecularecologicalnetworkanalysisrevealstheeffectsofprobioticsandflorfenicolonintestinalmicrobiotahomeostasisanexampleofseacucumber AT shuanglindong molecularecologicalnetworkanalysisrevealstheeffectsofprobioticsandflorfenicolonintestinalmicrobiotahomeostasisanexampleofseacucumber
_version_	1718384798689394688

Molecular ecological network analysis reveals the effects of probiotics and florfenicol on intestinal microbiota homeostasis: An example of sea cucumber

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