Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease

Background: Resting tremor is a cardinal symptom of Parkinson’s disease (PD) that contributes to the physical, emotional, and economic burden of the disease.Objective: The goal of this study was to investigate the safety, tolerability, and preliminary effectiveness of a novel wearable vibrotactile s...

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Autores principales:	Laura Tabacof, Stephen Braren, Taylor Patterson, Adam Fry, David Putrino
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease resting tremor wearable technologies vibration UPDRS vibrotactile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/acd899691b2c4b6199e679defdd52a91
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spelling	oai:doaj.org-article:acd899691b2c4b6199e679defdd52a912021-11-18T06:50:36ZSafety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease1662-516110.3389/fnhum.2021.712621https://doaj.org/article/acd899691b2c4b6199e679defdd52a912021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.712621/fullhttps://doaj.org/toc/1662-5161Background: Resting tremor is a cardinal symptom of Parkinson’s disease (PD) that contributes to the physical, emotional, and economic burden of the disease.Objective: The goal of this study was to investigate the safety, tolerability, and preliminary effectiveness of a novel wearable vibrotactile stimulation device on resting tremor in individuals with PD.Methods: Using a randomized cross-over design, subjects received two different vibrotactile stimulation paradigms (high amplitude patterned and low amplitude continuous) on two separate laboratory visits. On each visit, resting tremor was video recorded for 10 min at baseline and while the vibrotactile stimulation was applied. Tremor severity was scored by a blinded clinician.Results: Both vibration paradigms were well safe and well tolerated and resulted in a reduction in resting tremor severity with a moderate effect size (n = 44, p < 0.001, r = 0.37–0.54). There was no significant difference between the two vibration paradigms (p = 0.14).Conclusion: Short durations of vibrotactile stimulation delivered via wearable devices were safe and well tolerated and may attenuate resting tremor severity in individuals with PD. The sample size as well as the potential preliminary effectiveness revealed by two arms of the study could not eliminate the potential for a placebo effect.Laura TabacofStephen BrarenTaylor PattersonAdam FryDavid PutrinoFrontiers Media S.A.articleParkinson’s diseaseresting tremorwearable technologiesvibrationUPDRSvibrotactileNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease resting tremor wearable technologies vibration UPDRS vibrotactile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Parkinson’s disease resting tremor wearable technologies vibration UPDRS vibrotactile Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Laura Tabacof Stephen Braren Taylor Patterson Adam Fry David Putrino Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
description	Background: Resting tremor is a cardinal symptom of Parkinson’s disease (PD) that contributes to the physical, emotional, and economic burden of the disease.Objective: The goal of this study was to investigate the safety, tolerability, and preliminary effectiveness of a novel wearable vibrotactile stimulation device on resting tremor in individuals with PD.Methods: Using a randomized cross-over design, subjects received two different vibrotactile stimulation paradigms (high amplitude patterned and low amplitude continuous) on two separate laboratory visits. On each visit, resting tremor was video recorded for 10 min at baseline and while the vibrotactile stimulation was applied. Tremor severity was scored by a blinded clinician.Results: Both vibration paradigms were well safe and well tolerated and resulted in a reduction in resting tremor severity with a moderate effect size (n = 44, p < 0.001, r = 0.37–0.54). There was no significant difference between the two vibration paradigms (p = 0.14).Conclusion: Short durations of vibrotactile stimulation delivered via wearable devices were safe and well tolerated and may attenuate resting tremor severity in individuals with PD. The sample size as well as the potential preliminary effectiveness revealed by two arms of the study could not eliminate the potential for a placebo effect.
format	article
author	Laura Tabacof Stephen Braren Taylor Patterson Adam Fry David Putrino
author_facet	Laura Tabacof Stephen Braren Taylor Patterson Adam Fry David Putrino
author_sort	Laura Tabacof
title	Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
title_short	Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
title_full	Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
title_fullStr	Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
title_full_unstemmed	Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease
title_sort	safety and tolerability of a wearable, vibrotactile stimulation device for parkinson’s disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/acd899691b2c4b6199e679defdd52a91
work_keys_str_mv	AT lauratabacof safetyandtolerabilityofawearablevibrotactilestimulationdeviceforparkinsonsdisease AT stephenbraren safetyandtolerabilityofawearablevibrotactilestimulationdeviceforparkinsonsdisease AT taylorpatterson safetyandtolerabilityofawearablevibrotactilestimulationdeviceforparkinsonsdisease AT adamfry safetyandtolerabilityofawearablevibrotactilestimulationdeviceforparkinsonsdisease AT davidputrino safetyandtolerabilityofawearablevibrotactilestimulationdeviceforparkinsonsdisease
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Safety and Tolerability of a Wearable, Vibrotactile Stimulation Device for Parkinson’s Disease

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