Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets.

Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein that turns off Gq signaling in platelets. RGS18 is regulated by binding to the adaptor protein 14-3-3 via phosphorylated serine residues S49 and S218 on RGS18. In this study we confirm that thrombin, thromboxane A2, or ADP st...

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Autores principales: Kristina Gegenbauer, Zoltan Nagy, Albert Smolenski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/acd9242442494ee2b89a8b6f3631abe1
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