Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype

Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype

Abstract We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the role of the microenvironment for aberrant growth. Accountin...

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Autores principales: Jorge Fernandez-de-Cossio-Diaz, Andrea De Martino, Roberto Mulet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/acdfbc10cd054f6e83d572d0d68f32e0
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