DNA methylation directs microRNA biogenesis in mammalian cells

DNA methylation directs microRNA biogenesis in mammalian cells

Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.

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Autores principales: Ohad Glaich, Shivang Parikh, Rachel E. Bell, Keren Mekahel, Maya Donyo, Yodfat Leader, Ronna Shayevitch, Danna Sheinboim, Sivan Yannai, Dror Hollander, Ze’ev Melamed, Galit Lev-Maor, Gil Ast, Carmit Levy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/ace0740f21624dc8b8606e6fd012d471
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spelling oai:doaj.org-article:ace0740f21624dc8b8606e6fd012d4712021-12-02T13:23:54ZDNA methylation directs microRNA biogenesis in mammalian cells10.1038/s41467-019-13527-12041-1723https://doaj.org/article/ace0740f21624dc8b8606e6fd012d4712019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13527-1https://doaj.org/toc/2041-1723Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.Ohad GlaichShivang ParikhRachel E. BellKeren MekahelMaya DonyoYodfat LeaderRonna ShayevitchDanna SheinboimSivan YannaiDror HollanderZe’ev MelamedGalit Lev-MaorGil AstCarmit LevyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ohad Glaich
Shivang Parikh
Rachel E. Bell
Keren Mekahel
Maya Donyo
Yodfat Leader
Ronna Shayevitch
Danna Sheinboim
Sivan Yannai
Dror Hollander
Ze’ev Melamed
Galit Lev-Maor
Gil Ast
Carmit Levy
DNA methylation directs microRNA biogenesis in mammalian cells
description Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.
format article
author Ohad Glaich
Shivang Parikh
Rachel E. Bell
Keren Mekahel
Maya Donyo
Yodfat Leader
Ronna Shayevitch
Danna Sheinboim
Sivan Yannai
Dror Hollander
Ze’ev Melamed
Galit Lev-Maor
Gil Ast
Carmit Levy
author_facet Ohad Glaich
Shivang Parikh
Rachel E. Bell
Keren Mekahel
Maya Donyo
Yodfat Leader
Ronna Shayevitch
Danna Sheinboim
Sivan Yannai
Dror Hollander
Ze’ev Melamed
Galit Lev-Maor
Gil Ast
Carmit Levy
author_sort Ohad Glaich
title DNA methylation directs microRNA biogenesis in mammalian cells
title_short DNA methylation directs microRNA biogenesis in mammalian cells
title_full DNA methylation directs microRNA biogenesis in mammalian cells
title_fullStr DNA methylation directs microRNA biogenesis in mammalian cells
title_full_unstemmed DNA methylation directs microRNA biogenesis in mammalian cells
title_sort dna methylation directs microrna biogenesis in mammalian cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ace0740f21624dc8b8606e6fd012d471
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