DNA methylation directs microRNA biogenesis in mammalian cells

DNA methylation directs microRNA biogenesis in mammalian cells

Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.

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Auteurs principaux: Ohad Glaich, Shivang Parikh, Rachel E. Bell, Keren Mekahel, Maya Donyo, Yodfat Leader, Ronna Shayevitch, Danna Sheinboim, Sivan Yannai, Dror Hollander, Ze’ev Melamed, Galit Lev-Maor, Gil Ast, Carmit Levy
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
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Accès en ligne:https://doaj.org/article/ace0740f21624dc8b8606e6fd012d471
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Internet

https://doaj.org/article/ace0740f21624dc8b8606e6fd012d471

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