Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review

Algorithms can have several purposes in the clinical practice. There are different scales for causality imputation in DILI (Drug-Induced Liver Injury), but the applicability and validity of these for the HILI (Herb-Induced Liver Injury) evaluation is questionable for some scales. The purpose of the...

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Autores principales:	Pedro Felipe Soares, Maria Tereza Calchi Fanti Fernandes, Andréia de Santana Souza, Caio Medina Lopes, Darjore Amorim Carvalho dos Santos, Diogo Pereira Rodrigues Oliveira, Marcela Gottschald Pereira, Nilia Maria De Brito Lima Prado, Gecynalda Soares da Silva Gomes, Genário Santos, Junior, Raymundo Paraná
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Medicinal herbs Herbal products HILI Liver injury RUCAM Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ace1999ec4cc444a9bc1d755ea57a6ec
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spelling	oai:doaj.org-article:ace1999ec4cc444a9bc1d755ea57a6ec2021-11-18T04:46:08ZCausality imputation between herbal products and HILI: An algorithm evaluation in a systematic review1665-268110.1016/j.aohep.2021.100539https://doaj.org/article/ace1999ec4cc444a9bc1d755ea57a6ec2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1665268121002386https://doaj.org/toc/1665-2681Algorithms can have several purposes in the clinical practice. There are different scales for causality imputation in DILI (Drug-Induced Liver Injury), but the applicability and validity of these for the HILI (Herb-Induced Liver Injury) evaluation is questionable for some scales. The purpose of the study was to determine the clinical and demographic profile of the patients with HILI, and the main algorithmic scales used in its causality assessment. The methodology was a systematic review of articles in English, Spanish, or Portuguese language, from 1979 to 2019, involving humans, with descriptors related to HILI. Qualitative and quantitative statistical analysis were performed. As a result, from a total of 60 articles, 203 HILI reports were selected: 59.9% were women, similar with other studies, and the average age was 45.8 years. Jaundice was the most frequent symptom and regarding the type of lesion, the hepatocellular was the most frequent. In regard to HILI severity, 3.0% were severe and 7.6% were fatal or required liver transplantation. In 72.3% of the cases, the most used algorithm was RUCAM (Roussel Uclaf Causality Assessment Method). The conclusion of the study is that RUCAM was the most used algorithm for causality assessment in HILI. The patients were predominantly female, jaundice was the main symptom, and HILI is reversible in the majority of cases.Pedro Felipe SoaresMaria Tereza Calchi Fanti FernandesAndréia de Santana SouzaCaio Medina LopesDarjore Amorim Carvalho dos SantosDiogo Pereira Rodrigues OliveiraMarcela Gottschald PereiraNilia Maria De Brito Lima PradoGecynalda Soares da Silva GomesGenário Santos, JuniorRaymundo ParanáElsevierarticleMedicinal herbsHerbal productsHILILiver injuryRUCAMSpecialties of internal medicineRC581-951ENAnnals of Hepatology, Vol 25, Iss , Pp 100539- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicinal herbs Herbal products HILI Liver injury RUCAM Specialties of internal medicine RC581-951
spellingShingle	Medicinal herbs Herbal products HILI Liver injury RUCAM Specialties of internal medicine RC581-951 Pedro Felipe Soares Maria Tereza Calchi Fanti Fernandes Andréia de Santana Souza Caio Medina Lopes Darjore Amorim Carvalho dos Santos Diogo Pereira Rodrigues Oliveira Marcela Gottschald Pereira Nilia Maria De Brito Lima Prado Gecynalda Soares da Silva Gomes Genário Santos, Junior Raymundo Paraná Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
description	Algorithms can have several purposes in the clinical practice. There are different scales for causality imputation in DILI (Drug-Induced Liver Injury), but the applicability and validity of these for the HILI (Herb-Induced Liver Injury) evaluation is questionable for some scales. The purpose of the study was to determine the clinical and demographic profile of the patients with HILI, and the main algorithmic scales used in its causality assessment. The methodology was a systematic review of articles in English, Spanish, or Portuguese language, from 1979 to 2019, involving humans, with descriptors related to HILI. Qualitative and quantitative statistical analysis were performed. As a result, from a total of 60 articles, 203 HILI reports were selected: 59.9% were women, similar with other studies, and the average age was 45.8 years. Jaundice was the most frequent symptom and regarding the type of lesion, the hepatocellular was the most frequent. In regard to HILI severity, 3.0% were severe and 7.6% were fatal or required liver transplantation. In 72.3% of the cases, the most used algorithm was RUCAM (Roussel Uclaf Causality Assessment Method). The conclusion of the study is that RUCAM was the most used algorithm for causality assessment in HILI. The patients were predominantly female, jaundice was the main symptom, and HILI is reversible in the majority of cases.
format	article
author	Pedro Felipe Soares Maria Tereza Calchi Fanti Fernandes Andréia de Santana Souza Caio Medina Lopes Darjore Amorim Carvalho dos Santos Diogo Pereira Rodrigues Oliveira Marcela Gottschald Pereira Nilia Maria De Brito Lima Prado Gecynalda Soares da Silva Gomes Genário Santos, Junior Raymundo Paraná
author_facet	Pedro Felipe Soares Maria Tereza Calchi Fanti Fernandes Andréia de Santana Souza Caio Medina Lopes Darjore Amorim Carvalho dos Santos Diogo Pereira Rodrigues Oliveira Marcela Gottschald Pereira Nilia Maria De Brito Lima Prado Gecynalda Soares da Silva Gomes Genário Santos, Junior Raymundo Paraná
author_sort	Pedro Felipe Soares
title	Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
title_short	Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
title_full	Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
title_fullStr	Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
title_full_unstemmed	Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review
title_sort	causality imputation between herbal products and hili: an algorithm evaluation in a systematic review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ace1999ec4cc444a9bc1d755ea57a6ec
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Causality imputation between herbal products and HILI: An algorithm evaluation in a systematic review

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