Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study

Jing-Hong Liu,1 Qing-Hua Ma,2 Yong Xu,1 Xing Chen,3 Chen-Wei Pan1 1School of Public Health, Medical College of Soochow University, Suzhou, People’s Republic of China; 2The 3rd People’s Hospital of Xiangcheng District, Suzhou, People’s Republic of China; 3Department of C...

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Autores principales:	Liu JH, Ma QH, Xu Y, Chen X, Pan CW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	hyperuricemia metabolic syndrome older adults epidemiology Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ace37e2cc5704f0b90e4aa5c6cd9f9cf
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spelling	oai:doaj.org-article:ace37e2cc5704f0b90e4aa5c6cd9f9cf2021-12-02T11:14:55ZMetabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study1178-7007https://doaj.org/article/ace37e2cc5704f0b90e4aa5c6cd9f9cf2020-11-01T00:00:00Zhttps://www.dovepress.com/metabolic-syndrome-and-5-year-incident-hyperuricemia-among-older-chine-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jing-Hong Liu,1 Qing-Hua Ma,2 Yong Xu,1 Xing Chen,3 Chen-Wei Pan1 1School of Public Health, Medical College of Soochow University, Suzhou, People’s Republic of China; 2The 3rd People’s Hospital of Xiangcheng District, Suzhou, People’s Republic of China; 3Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of ChinaCorrespondence: Xing ChenDepartment of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, No. 26 Dao Qian Road, Suzhou 215000, People’s Republic of ChinaTel +86 512 62362193Email cx1708@126.comChen-Wei PanSchool of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou 215123, People’s Republic of ChinaTel +86 512 65883907Email pcwonly@gmail.comBackground: There was a lack of studies focusing on older adults about the longitudinal association between metabolic syndrome (MetS) and hyperuricemia (HUA). We aimed to assess the association of baseline MetS and incident HUA among older Chinese adults, with a special focus on the associations between different combinations of MetS components and HUA.Methods: Data of 3247 Chinese adults aged 60 years or older included in a community-based longitudinal cohort study were analyzed. Anthropometric examinations and collection of blood sample were conducted both at baseline and follow-up. HUA was defined as 7 mg/dl or above for men and 6 mg/dl or greater for women. MetS was assessed based on the National Cholesterol Education Program-Adult Treatment Panel III, and older adults with the presence of at least three of MetS components were considered as having MetS.Results: MetS and its components, including high blood pressure (BP), high body mass index, diabetes mellitus and high triglycerides, were significantly related to incident HUA. The association between high BP and incident HUA is strongest among the five MetS components. Among all combinations of MetS components, the group consisting of diabetes mellitus, high BP and high triglycerides had the highest odds for incident HUA (OR = 13.07, 95% CI = 4.95– 34.54).Conclusion: MetS and its components, except for low high-density lipoprotein cholesterol, could increase the risk of HUA among community-dwelling older adults, and high BP may be the most important determinant.Keywords: hyperuricemia, metabolic syndrome, older adults, epidemiologyLiu JHMa QHXu YChen XPan CWDove Medical Pressarticlehyperuricemiametabolic syndromeolder adultsepidemiologySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4191-4200 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperuricemia metabolic syndrome older adults epidemiology Specialties of internal medicine RC581-951
spellingShingle	hyperuricemia metabolic syndrome older adults epidemiology Specialties of internal medicine RC581-951 Liu JH Ma QH Xu Y Chen X Pan CW Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
description	Jing-Hong Liu,1 Qing-Hua Ma,2 Yong Xu,1 Xing Chen,3 Chen-Wei Pan1 1School of Public Health, Medical College of Soochow University, Suzhou, People’s Republic of China; 2The 3rd People’s Hospital of Xiangcheng District, Suzhou, People’s Republic of China; 3Department of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of ChinaCorrespondence: Xing ChenDepartment of Children Health Care, Affiliated Suzhou Hospital of Nanjing Medical University, No. 26 Dao Qian Road, Suzhou 215000, People’s Republic of ChinaTel +86 512 62362193Email cx1708@126.comChen-Wei PanSchool of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou 215123, People’s Republic of ChinaTel +86 512 65883907Email pcwonly@gmail.comBackground: There was a lack of studies focusing on older adults about the longitudinal association between metabolic syndrome (MetS) and hyperuricemia (HUA). We aimed to assess the association of baseline MetS and incident HUA among older Chinese adults, with a special focus on the associations between different combinations of MetS components and HUA.Methods: Data of 3247 Chinese adults aged 60 years or older included in a community-based longitudinal cohort study were analyzed. Anthropometric examinations and collection of blood sample were conducted both at baseline and follow-up. HUA was defined as 7 mg/dl or above for men and 6 mg/dl or greater for women. MetS was assessed based on the National Cholesterol Education Program-Adult Treatment Panel III, and older adults with the presence of at least three of MetS components were considered as having MetS.Results: MetS and its components, including high blood pressure (BP), high body mass index, diabetes mellitus and high triglycerides, were significantly related to incident HUA. The association between high BP and incident HUA is strongest among the five MetS components. Among all combinations of MetS components, the group consisting of diabetes mellitus, high BP and high triglycerides had the highest odds for incident HUA (OR = 13.07, 95% CI = 4.95– 34.54).Conclusion: MetS and its components, except for low high-density lipoprotein cholesterol, could increase the risk of HUA among community-dwelling older adults, and high BP may be the most important determinant.Keywords: hyperuricemia, metabolic syndrome, older adults, epidemiology
format	article
author	Liu JH Ma QH Xu Y Chen X Pan CW
author_facet	Liu JH Ma QH Xu Y Chen X Pan CW
author_sort	Liu JH
title	Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
title_short	Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
title_full	Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
title_fullStr	Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
title_full_unstemmed	Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study
title_sort	metabolic syndrome and 5-year incident hyperuricemia among older chinese adults: a community-based cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ace37e2cc5704f0b90e4aa5c6cd9f9cf
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Metabolic Syndrome and 5-Year Incident Hyperuricemia Among Older Chinese Adults: A Community-Based Cohort Study

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