Impaired cortico-striatal excitatory transmission triggers epilepsy

Impaired cortico-striatal excitatory transmission triggers epilepsy

Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.

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Autores principales: Hiroyuki Miyamoto, Tetsuya Tatsukawa, Atsushi Shimohata, Tetsushi Yamagata, Toshimitsu Suzuki, Kenji Amano, Emi Mazaki, Matthieu Raveau, Ikuo Ogiwara, Atsuko Oba-Asaka, Takao K. Hensch, Shigeyoshi Itohara, Kenji Sakimura, Kenta Kobayashi, Kazuto Kobayashi, Kazuhiro Yamakawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb0
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spelling oai:doaj.org-article:ace6b971d0ec4f8d94660e10cc120cb02021-12-02T14:39:39ZImpaired cortico-striatal excitatory transmission triggers epilepsy10.1038/s41467-019-09954-92041-1723https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb02019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09954-9https://doaj.org/toc/2041-1723Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.Hiroyuki MiyamotoTetsuya TatsukawaAtsushi ShimohataTetsushi YamagataToshimitsu SuzukiKenji AmanoEmi MazakiMatthieu RaveauIkuo OgiwaraAtsuko Oba-AsakaTakao K. HenschShigeyoshi ItoharaKenji SakimuraKenta KobayashiKazuto KobayashiKazuhiro YamakawaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hiroyuki Miyamoto
Tetsuya Tatsukawa
Atsushi Shimohata
Tetsushi Yamagata
Toshimitsu Suzuki
Kenji Amano
Emi Mazaki
Matthieu Raveau
Ikuo Ogiwara
Atsuko Oba-Asaka
Takao K. Hensch
Shigeyoshi Itohara
Kenji Sakimura
Kenta Kobayashi
Kazuto Kobayashi
Kazuhiro Yamakawa
Impaired cortico-striatal excitatory transmission triggers epilepsy
description Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.
format article
author Hiroyuki Miyamoto
Tetsuya Tatsukawa
Atsushi Shimohata
Tetsushi Yamagata
Toshimitsu Suzuki
Kenji Amano
Emi Mazaki
Matthieu Raveau
Ikuo Ogiwara
Atsuko Oba-Asaka
Takao K. Hensch
Shigeyoshi Itohara
Kenji Sakimura
Kenta Kobayashi
Kazuto Kobayashi
Kazuhiro Yamakawa
author_facet Hiroyuki Miyamoto
Tetsuya Tatsukawa
Atsushi Shimohata
Tetsushi Yamagata
Toshimitsu Suzuki
Kenji Amano
Emi Mazaki
Matthieu Raveau
Ikuo Ogiwara
Atsuko Oba-Asaka
Takao K. Hensch
Shigeyoshi Itohara
Kenji Sakimura
Kenta Kobayashi
Kazuto Kobayashi
Kazuhiro Yamakawa
author_sort Hiroyuki Miyamoto
title Impaired cortico-striatal excitatory transmission triggers epilepsy
title_short Impaired cortico-striatal excitatory transmission triggers epilepsy
title_full Impaired cortico-striatal excitatory transmission triggers epilepsy
title_fullStr Impaired cortico-striatal excitatory transmission triggers epilepsy
title_full_unstemmed Impaired cortico-striatal excitatory transmission triggers epilepsy
title_sort impaired cortico-striatal excitatory transmission triggers epilepsy
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb0
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