Impaired cortico-striatal excitatory transmission triggers epilepsy

Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.

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Auteurs principaux:	Hiroyuki Miyamoto, Tetsuya Tatsukawa, Atsushi Shimohata, Tetsushi Yamagata, Toshimitsu Suzuki, Kenji Amano, Emi Mazaki, Matthieu Raveau, Ikuo Ogiwara, Atsuko Oba-Asaka, Takao K. Hensch, Shigeyoshi Itohara, Kenji Sakimura, Kenta Kobayashi, Kazuto Kobayashi, Kazuhiro Yamakawa
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb0
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spelling	oai:doaj.org-article:ace6b971d0ec4f8d94660e10cc120cb02021-12-02T14:39:39ZImpaired cortico-striatal excitatory transmission triggers epilepsy10.1038/s41467-019-09954-92041-1723https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb02019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09954-9https://doaj.org/toc/2041-1723Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.Hiroyuki MiyamotoTetsuya TatsukawaAtsushi ShimohataTetsushi YamagataToshimitsu SuzukiKenji AmanoEmi MazakiMatthieu RaveauIkuo OgiwaraAtsuko Oba-AsakaTakao K. HenschShigeyoshi ItoharaKenji SakimuraKenta KobayashiKazuto KobayashiKazuhiro YamakawaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroyuki Miyamoto Tetsuya Tatsukawa Atsushi Shimohata Tetsushi Yamagata Toshimitsu Suzuki Kenji Amano Emi Mazaki Matthieu Raveau Ikuo Ogiwara Atsuko Oba-Asaka Takao K. Hensch Shigeyoshi Itohara Kenji Sakimura Kenta Kobayashi Kazuto Kobayashi Kazuhiro Yamakawa Impaired cortico-striatal excitatory transmission triggers epilepsy
description	Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.
format	article
author	Hiroyuki Miyamoto Tetsuya Tatsukawa Atsushi Shimohata Tetsushi Yamagata Toshimitsu Suzuki Kenji Amano Emi Mazaki Matthieu Raveau Ikuo Ogiwara Atsuko Oba-Asaka Takao K. Hensch Shigeyoshi Itohara Kenji Sakimura Kenta Kobayashi Kazuto Kobayashi Kazuhiro Yamakawa
author_facet	Hiroyuki Miyamoto Tetsuya Tatsukawa Atsushi Shimohata Tetsushi Yamagata Toshimitsu Suzuki Kenji Amano Emi Mazaki Matthieu Raveau Ikuo Ogiwara Atsuko Oba-Asaka Takao K. Hensch Shigeyoshi Itohara Kenji Sakimura Kenta Kobayashi Kazuto Kobayashi Kazuhiro Yamakawa
author_sort	Hiroyuki Miyamoto
title	Impaired cortico-striatal excitatory transmission triggers epilepsy
title_short	Impaired cortico-striatal excitatory transmission triggers epilepsy
title_full	Impaired cortico-striatal excitatory transmission triggers epilepsy
title_fullStr	Impaired cortico-striatal excitatory transmission triggers epilepsy
title_full_unstemmed	Impaired cortico-striatal excitatory transmission triggers epilepsy
title_sort	impaired cortico-striatal excitatory transmission triggers epilepsy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ace6b971d0ec4f8d94660e10cc120cb0
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Impaired cortico-striatal excitatory transmission triggers epilepsy

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