Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Arsenic trioxide and all-trans retinoic acid combination safely cures human acute promyelocytic leukemia. Here, the authors show that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master  regulator of oncogenic signaling networks,...

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Autores principales: Shingo Kozono, Yu-Min Lin, Hyuk-Soo Seo, Benika Pinch, Xiaolan Lian, Chenxi Qiu, Megan K. Herbert, Chun-Hau Chen, Li Tan, Ziang Jeff Gao, Walter Massefski, Zainab M. Doctor, Brian P. Jackson, Yuanzhong Chen, Sirano Dhe-Paganon, Kun Ping Lu, Xiao Zhen Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/acea0fc0a384452499f5273e12f88166
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spelling oai:doaj.org-article:acea0fc0a384452499f5273e12f881662021-12-02T15:33:55ZArsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells10.1038/s41467-018-05402-22041-1723https://doaj.org/article/acea0fc0a384452499f5273e12f881662018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05402-2https://doaj.org/toc/2041-1723Arsenic trioxide and all-trans retinoic acid combination safely cures human acute promyelocytic leukemia. Here, the authors show that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master  regulator of oncogenic signaling networks, to eliminate cancer stem cells.Shingo KozonoYu-Min LinHyuk-Soo SeoBenika PinchXiaolan LianChenxi QiuMegan K. HerbertChun-Hau ChenLi TanZiang Jeff GaoWalter MassefskiZainab M. DoctorBrian P. JacksonYuanzhong ChenSirano Dhe-PaganonKun Ping LuXiao Zhen ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shingo Kozono
Yu-Min Lin
Hyuk-Soo Seo
Benika Pinch
Xiaolan Lian
Chenxi Qiu
Megan K. Herbert
Chun-Hau Chen
Li Tan
Ziang Jeff Gao
Walter Massefski
Zainab M. Doctor
Brian P. Jackson
Yuanzhong Chen
Sirano Dhe-Paganon
Kun Ping Lu
Xiao Zhen Zhou
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
description Arsenic trioxide and all-trans retinoic acid combination safely cures human acute promyelocytic leukemia. Here, the authors show that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master  regulator of oncogenic signaling networks, to eliminate cancer stem cells.
format article
author Shingo Kozono
Yu-Min Lin
Hyuk-Soo Seo
Benika Pinch
Xiaolan Lian
Chenxi Qiu
Megan K. Herbert
Chun-Hau Chen
Li Tan
Ziang Jeff Gao
Walter Massefski
Zainab M. Doctor
Brian P. Jackson
Yuanzhong Chen
Sirano Dhe-Paganon
Kun Ping Lu
Xiao Zhen Zhou
author_facet Shingo Kozono
Yu-Min Lin
Hyuk-Soo Seo
Benika Pinch
Xiaolan Lian
Chenxi Qiu
Megan K. Herbert
Chun-Hau Chen
Li Tan
Ziang Jeff Gao
Walter Massefski
Zainab M. Doctor
Brian P. Jackson
Yuanzhong Chen
Sirano Dhe-Paganon
Kun Ping Lu
Xiao Zhen Zhou
author_sort Shingo Kozono
title Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
title_short Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
title_full Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
title_fullStr Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
title_full_unstemmed Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
title_sort arsenic targets pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/acea0fc0a384452499f5273e12f88166
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