Glutathione for skin lightning: A regnant myth or evidence-based verity

The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a “wonder” drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surg...

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Autores principales:	Sidharth Sonthalia, Abhijeet Kumar Jha, Aimilios Lallas, Geraldine Jain, Deepak Jhakar
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2018
Materias:	glutathione skin lightning intravenous GSH GSSG Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/acec45d9c5074243b319e2aed71a413b
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spelling	oai:doaj.org-article:acec45d9c5074243b319e2aed71a413b2021-11-17T08:30:26ZGlutathione for skin lightning: A regnant myth or evidence-based verity2160-9381https://doaj.org/article/acec45d9c5074243b319e2aed71a413b2018-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/328https://doaj.org/toc/2160-9381 The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a “wonder” drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies. Even though parenteral glutathione is approved only for severe liver disorders and for prevention of chemotherapy associated neurotoxicity, the lack of statutory laws governing the use of systemic glutathione in most countries has contributed to its unchecked use for skin lightening. The current clinical evidence of intravenous glutathione for skin lightening is limited to a single study with a dubious study design and apparently flawed analysis of results, casting doubt on the drug's efficacy and reported adverse effects. Two studies evaluating oral/sublingual administration and one trial involving the use of topical glutathione reported good safety profile and appreciable but reversible results on skin tone. In this article, we shall review and discuss the current status of glutathione as a skin lightening agent and address the sundry unanswered queries regarding the dosage, duration of use and longevity of accrued effects based on clinical evidence and recent insights into its antimelanogenic mechanism. Sidharth SonthaliaAbhijeet Kumar JhaAimilios LallasGeraldine JainDeepak JhakarMattioli1885articleglutathioneskin lightningintravenousGSHGSSGDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 8, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	glutathione skin lightning intravenous GSH GSSG Dermatology RL1-803
spellingShingle	glutathione skin lightning intravenous GSH GSSG Dermatology RL1-803 Sidharth Sonthalia Abhijeet Kumar Jha Aimilios Lallas Geraldine Jain Deepak Jhakar Glutathione for skin lightning: A regnant myth or evidence-based verity
description	The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a “wonder” drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies. Even though parenteral glutathione is approved only for severe liver disorders and for prevention of chemotherapy associated neurotoxicity, the lack of statutory laws governing the use of systemic glutathione in most countries has contributed to its unchecked use for skin lightening. The current clinical evidence of intravenous glutathione for skin lightening is limited to a single study with a dubious study design and apparently flawed analysis of results, casting doubt on the drug's efficacy and reported adverse effects. Two studies evaluating oral/sublingual administration and one trial involving the use of topical glutathione reported good safety profile and appreciable but reversible results on skin tone. In this article, we shall review and discuss the current status of glutathione as a skin lightening agent and address the sundry unanswered queries regarding the dosage, duration of use and longevity of accrued effects based on clinical evidence and recent insights into its antimelanogenic mechanism.
format	article
author	Sidharth Sonthalia Abhijeet Kumar Jha Aimilios Lallas Geraldine Jain Deepak Jhakar
author_facet	Sidharth Sonthalia Abhijeet Kumar Jha Aimilios Lallas Geraldine Jain Deepak Jhakar
author_sort	Sidharth Sonthalia
title	Glutathione for skin lightning: A regnant myth or evidence-based verity
title_short	Glutathione for skin lightning: A regnant myth or evidence-based verity
title_full	Glutathione for skin lightning: A regnant myth or evidence-based verity
title_fullStr	Glutathione for skin lightning: A regnant myth or evidence-based verity
title_full_unstemmed	Glutathione for skin lightning: A regnant myth or evidence-based verity
title_sort	glutathione for skin lightning: a regnant myth or evidence-based verity
publisher	Mattioli1885
publishDate	2018
url	https://doaj.org/article/acec45d9c5074243b319e2aed71a413b
work_keys_str_mv	AT sidharthsonthalia glutathioneforskinlightningaregnantmythorevidencebasedverity AT abhijeetkumarjha glutathioneforskinlightningaregnantmythorevidencebasedverity AT aimilioslallas glutathioneforskinlightningaregnantmythorevidencebasedverity AT geraldinejain glutathioneforskinlightningaregnantmythorevidencebasedverity AT deepakjhakar glutathioneforskinlightningaregnantmythorevidencebasedverity
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Glutathione for skin lightning: A regnant myth or evidence-based verity

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