Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia

Getandale Zeleke Negera,1 Belachew Weldegebriel,1 Ginenus Fekadu2 1Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, EthiopiaCor...

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Autores principales:	Negera GZ, Weldegebriel B, Fekadu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	acute complications diabetic ketoacidosis hyperglycemic hyperosmolar state ethiopia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/acef101c1b9640c7b58fd572b84001b7
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spelling	oai:doaj.org-article:acef101c1b9640c7b58fd572b84001b72021-12-02T11:38:02ZAcute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia1178-7007https://doaj.org/article/acef101c1b9640c7b58fd572b84001b72020-04-01T00:00:00Zhttps://www.dovepress.com/acute-complications-of-diabetes-and-its-predictors-among-adult-diabeti-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Getandale Zeleke Negera,1 Belachew Weldegebriel,1 Ginenus Fekadu2 1Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, EthiopiaCorrespondence: Getandale Zeleke NegeraDepartment of Clinical Pharmacy, School of Pharmacy, Institute of Health Jimma University, PO Box 378, Jimma, EthiopiaTel +251 91 289 2539Email getandale@gmail.comBackground: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from impairment in insulin secretion, insulin action, or both. It is responsible for a wide range of acute and chronic complications. In this study, we aimed to assess acute complications of diabetes and its predictors among adult DM patients at Jimma Medical Center (JMC), southwest Ethiopia.Methods: A facility-based cross-sectional study involving 348 diabetic patients was conducted from February to May 31, 2019 at JMC. Logistic regression was conducted to identify predictors of acute complications of diabetes. Variables with P≤ 0.25 on bivariate logistic regression were considered candidates for multivariate regression. ORs and 95% CIs  with P< 0.05 were considered statistically significant.Results: Of the  348 patients, 225 (64.7%) were male, and the mean age of study participants was 46± 15.5 years. Most (281,  80.7%) had type 2 DM. More than two-thirds (240,  69%)had diabetes duration of < 5 years. During the study period, 92 (26.4%) patients developed acute complications of diabetes. Of these, 68 (73.9%) had diabetic ketoacidosis, 21 (22.8%) a hyperglycemic hyperosmolar state, and three (3.3%) hypoglycemia. Presence of comorbidity (AOR 5.6, 95% CI 2.80– 11.19), type 1 DM (AOR 9.3, 95% CI 4.36– 19.82), uncontrolled blood glucose (AOR 1.91, 95% CI 1.05– 3.45), and lack of access to a health facility within a reasonable distance (AOR 1.96, 95% CI 1.11– 3.45) were independent predictors of acute complications of diabetes.Conclusion: The magnitude of acute complications among DM patients at JMC was high. Comorbidity, type 1 DM, uncontrolled blood sugar, and lack of access to a health facility within a reasonable distance were independent predictors of acute complications. Clinicians should follow up this subgroup of DM patients closely.Keywords: acute complications, diabetic ketoacidosis, hyperglycemic hyperosmolar state, EthiopiaNegera GZWeldegebriel BFekadu GDove Medical Pressarticleacute complicationsdiabetic ketoacidosishyperglycemic hyperosmolar stateethiopiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 1237-1242 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute complications diabetic ketoacidosis hyperglycemic hyperosmolar state ethiopia Specialties of internal medicine RC581-951
spellingShingle	acute complications diabetic ketoacidosis hyperglycemic hyperosmolar state ethiopia Specialties of internal medicine RC581-951 Negera GZ Weldegebriel B Fekadu G Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
description	Getandale Zeleke Negera,1 Belachew Weldegebriel,1 Ginenus Fekadu2 1Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, EthiopiaCorrespondence: Getandale Zeleke NegeraDepartment of Clinical Pharmacy, School of Pharmacy, Institute of Health Jimma University, PO Box 378, Jimma, EthiopiaTel +251 91 289 2539Email getandale@gmail.comBackground: Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from impairment in insulin secretion, insulin action, or both. It is responsible for a wide range of acute and chronic complications. In this study, we aimed to assess acute complications of diabetes and its predictors among adult DM patients at Jimma Medical Center (JMC), southwest Ethiopia.Methods: A facility-based cross-sectional study involving 348 diabetic patients was conducted from February to May 31, 2019 at JMC. Logistic regression was conducted to identify predictors of acute complications of diabetes. Variables with P≤ 0.25 on bivariate logistic regression were considered candidates for multivariate regression. ORs and 95% CIs  with P< 0.05 were considered statistically significant.Results: Of the  348 patients, 225 (64.7%) were male, and the mean age of study participants was 46± 15.5 years. Most (281,  80.7%) had type 2 DM. More than two-thirds (240,  69%)had diabetes duration of < 5 years. During the study period, 92 (26.4%) patients developed acute complications of diabetes. Of these, 68 (73.9%) had diabetic ketoacidosis, 21 (22.8%) a hyperglycemic hyperosmolar state, and three (3.3%) hypoglycemia. Presence of comorbidity (AOR 5.6, 95% CI 2.80– 11.19), type 1 DM (AOR 9.3, 95% CI 4.36– 19.82), uncontrolled blood glucose (AOR 1.91, 95% CI 1.05– 3.45), and lack of access to a health facility within a reasonable distance (AOR 1.96, 95% CI 1.11– 3.45) were independent predictors of acute complications of diabetes.Conclusion: The magnitude of acute complications among DM patients at JMC was high. Comorbidity, type 1 DM, uncontrolled blood sugar, and lack of access to a health facility within a reasonable distance were independent predictors of acute complications. Clinicians should follow up this subgroup of DM patients closely.Keywords: acute complications, diabetic ketoacidosis, hyperglycemic hyperosmolar state, Ethiopia
format	article
author	Negera GZ Weldegebriel B Fekadu G
author_facet	Negera GZ Weldegebriel B Fekadu G
author_sort	Negera GZ
title	Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
title_short	Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
title_full	Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
title_fullStr	Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
title_full_unstemmed	Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia
title_sort	acute complications of diabetes and its predictors among adult diabetic patients at jimma medical center, southwest ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/acef101c1b9640c7b58fd572b84001b7
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Acute Complications of Diabetes and its Predictors among Adult Diabetic Patients at Jimma Medical Center, Southwest Ethiopia

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