Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma.
<h4>Background</h4>Malignant mesothelioma (MM) is a rare, highly aggressive tumor, associated to asbestos exposure. To date no chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be developed. We have previously shown in vivo tha...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2011
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/acef1d49b26b4ff8a14a7824a0ed1cc5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:acef1d49b26b4ff8a14a7824a0ed1cc5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:acef1d49b26b4ff8a14a7824a0ed1cc52021-11-18T06:47:46ZApoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma.1932-620310.1371/journal.pone.0023569https://doaj.org/article/acef1d49b26b4ff8a14a7824a0ed1cc52011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858171/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Malignant mesothelioma (MM) is a rare, highly aggressive tumor, associated to asbestos exposure. To date no chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be developed. We have previously shown in vivo that piroxicam/cisplatin combined treatment in MM, specifically acts on cell cycle regulation triggering apoptosis, with survival increase.<h4>Methodology/principal findings</h4>We analyzed, at molecular level, the apoptotic increase caused by piroxicam/cisplatin treatment in MM cell lines. By means of genome wide analyses, we analyzed transcriptional gene deregulation both after the single piroxicam or cisplatin and the combined treatment. Here we show that apoptotic increase following combined treatment is mediated by p21, since apoptotic increase in piroxicam/cisplatin combined treatment is abolished upon p21 silencing.<h4>Conclusions/significance</h4>Piroxicam/cisplatin combined treatment determines an apoptosis increase in MM cells, which is dependent on the p21 expression. The results provided suggest that piroxicam/cisplatin combination might be tested in clinical settings in tumor specimens that express p21.Alfonso BaldiMaria Teresa PiccoloMaria Rosaria BoccellinoAldo DonizettiIrene CardilloRaffaele La PortaLucio QuagliuoloEnrico P SpugniniFrancesca CorderoGennaro CitroMassimo MenegozzoRaffaele A CalogeroStefania CrispiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23569 (2011) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Alfonso Baldi Maria Teresa Piccolo Maria Rosaria Boccellino Aldo Donizetti Irene Cardillo Raffaele La Porta Lucio Quagliuolo Enrico P Spugnini Francesca Cordero Gennaro Citro Massimo Menegozzo Raffaele A Calogero Stefania Crispi Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| description |
<h4>Background</h4>Malignant mesothelioma (MM) is a rare, highly aggressive tumor, associated to asbestos exposure. To date no chemotherapy regimen for MM has proven to be definitively curative, and new therapies for MM treatment need to be developed. We have previously shown in vivo that piroxicam/cisplatin combined treatment in MM, specifically acts on cell cycle regulation triggering apoptosis, with survival increase.<h4>Methodology/principal findings</h4>We analyzed, at molecular level, the apoptotic increase caused by piroxicam/cisplatin treatment in MM cell lines. By means of genome wide analyses, we analyzed transcriptional gene deregulation both after the single piroxicam or cisplatin and the combined treatment. Here we show that apoptotic increase following combined treatment is mediated by p21, since apoptotic increase in piroxicam/cisplatin combined treatment is abolished upon p21 silencing.<h4>Conclusions/significance</h4>Piroxicam/cisplatin combined treatment determines an apoptosis increase in MM cells, which is dependent on the p21 expression. The results provided suggest that piroxicam/cisplatin combination might be tested in clinical settings in tumor specimens that express p21. |
| format |
article |
| author |
Alfonso Baldi Maria Teresa Piccolo Maria Rosaria Boccellino Aldo Donizetti Irene Cardillo Raffaele La Porta Lucio Quagliuolo Enrico P Spugnini Francesca Cordero Gennaro Citro Massimo Menegozzo Raffaele A Calogero Stefania Crispi |
| author_facet |
Alfonso Baldi Maria Teresa Piccolo Maria Rosaria Boccellino Aldo Donizetti Irene Cardillo Raffaele La Porta Lucio Quagliuolo Enrico P Spugnini Francesca Cordero Gennaro Citro Massimo Menegozzo Raffaele A Calogero Stefania Crispi |
| author_sort |
Alfonso Baldi |
| title |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| title_short |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| title_full |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| title_fullStr |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| title_full_unstemmed |
Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| title_sort |
apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/acef1d49b26b4ff8a14a7824a0ed1cc5 |
| work_keys_str_mv |
AT alfonsobaldi apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT mariateresapiccolo apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT mariarosariaboccellino apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT aldodonizetti apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT irenecardillo apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT raffaelelaporta apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT lucioquagliuolo apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT enricopspugnini apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT francescacordero apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT gennarocitro apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT massimomenegozzo apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT raffaeleacalogero apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma AT stefaniacrispi apoptosisinducedbypiroxicampluscisplatincombinedtreatmentistriggeredbyp21inmesothelioma |
| _version_ |
1718424373463875584 |