Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease

AIM: To explore the characteristics and application value of ultra-wide-field auto-fluorescence in Stargardt disease. METHODS: A retrospective study of clinical characteristics and genetically confirmed Stargardt disease patients, using Optos P200Tx for ultra-wide-field auto-fluorescence imaging, an...

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Autores principales:	Zhi-Kun Zheng, Juan Zhang, Hua Li, Juan-Juan Li
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	auto-fluorescence fundus flavimaculatus stargardt disease ultra-wide field Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/acf3ec1fe07d4630ab84bebc73e959ab
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spelling	oai:doaj.org-article:acf3ec1fe07d4630ab84bebc73e959ab2021-11-22T14:22:33ZCharacteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease1672-512310.3980/j.issn.1672-5123.2021.12.34https://doaj.org/article/acf3ec1fe07d4630ab84bebc73e959ab2021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112034.pdfhttps://doaj.org/toc/1672-5123AIM: To explore the characteristics and application value of ultra-wide-field auto-fluorescence in Stargardt disease. METHODS: A retrospective study of clinical characteristics and genetically confirmed Stargardt disease patients, using Optos P200Tx for ultra-wide-field auto-fluorescence imaging, and comparing the imaging features of traditional fundus color photographs, fundus 55° auto-fluorescence, and optical coherence tomography, to evaluate the ultra-wide-field auto-fluorescence in Stargardt disease image characteristics and advantages of clinical application. RESULTS:All 76 eyes(100%)had high posterior auto-fluorescence, while only 42 eyes(55%)of traditional 55° auto-fluorescence showed obvious posterior high auto-fluorescence. Sixty-six eyes(87%)of the 76 eyes showed different numbers of spots, which were distributed from the posterior pole to the peripheral retina. UWAF can show clearer and more number of retinal spots than fundus color photographs, and more completely shows the number and distribution of spots area. All 76 eyes(100%)of the patients showed the oval low auto-fluorescence area induced by retinal pigment epithelium(RPE)atrophy in the center of the macula. As the disease progressed, the atrophy area expanded and the low fluorescence area expanded accordingly. Ultra-wide-field auto-fluorescence can completely display the atrophy range and area, but it cannot display in dystrophy depth. In 48 eyes(63%)ultra-wide-field auto-fluorescence, strong background auto-fluorescence was seen extending from the macula to the nasal and inferior temporal of the optic disc, forming a clear approximately vertical dividing line below the optic disc.CONCLUSION: Ultra-wide-field auto-fluorescence changes in Stargardt are not limited to the posterior pole and may extend more peripherally. Ultra-wide-field imaging is a useful tool for the assessment of patients with Stargardt macular dystrophy.Zhi-Kun ZhengJuan ZhangHua LiJuan-Juan LiPress of International Journal of Ophthalmology (IJO PRESS)articleauto-fluorescencefundus flavimaculatusstargardt diseaseultra-wide fieldOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2191-2194 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	auto-fluorescence fundus flavimaculatus stargardt disease ultra-wide field Ophthalmology RE1-994
spellingShingle	auto-fluorescence fundus flavimaculatus stargardt disease ultra-wide field Ophthalmology RE1-994 Zhi-Kun Zheng Juan Zhang Hua Li Juan-Juan Li Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
description	AIM: To explore the characteristics and application value of ultra-wide-field auto-fluorescence in Stargardt disease. METHODS: A retrospective study of clinical characteristics and genetically confirmed Stargardt disease patients, using Optos P200Tx for ultra-wide-field auto-fluorescence imaging, and comparing the imaging features of traditional fundus color photographs, fundus 55° auto-fluorescence, and optical coherence tomography, to evaluate the ultra-wide-field auto-fluorescence in Stargardt disease image characteristics and advantages of clinical application. RESULTS:All 76 eyes(100%)had high posterior auto-fluorescence, while only 42 eyes(55%)of traditional 55° auto-fluorescence showed obvious posterior high auto-fluorescence. Sixty-six eyes(87%)of the 76 eyes showed different numbers of spots, which were distributed from the posterior pole to the peripheral retina. UWAF can show clearer and more number of retinal spots than fundus color photographs, and more completely shows the number and distribution of spots area. All 76 eyes(100%)of the patients showed the oval low auto-fluorescence area induced by retinal pigment epithelium(RPE)atrophy in the center of the macula. As the disease progressed, the atrophy area expanded and the low fluorescence area expanded accordingly. Ultra-wide-field auto-fluorescence can completely display the atrophy range and area, but it cannot display in dystrophy depth. In 48 eyes(63%)ultra-wide-field auto-fluorescence, strong background auto-fluorescence was seen extending from the macula to the nasal and inferior temporal of the optic disc, forming a clear approximately vertical dividing line below the optic disc.CONCLUSION: Ultra-wide-field auto-fluorescence changes in Stargardt are not limited to the posterior pole and may extend more peripherally. Ultra-wide-field imaging is a useful tool for the assessment of patients with Stargardt macular dystrophy.
format	article
author	Zhi-Kun Zheng Juan Zhang Hua Li Juan-Juan Li
author_facet	Zhi-Kun Zheng Juan Zhang Hua Li Juan-Juan Li
author_sort	Zhi-Kun Zheng
title	Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
title_short	Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
title_full	Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
title_fullStr	Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
title_full_unstemmed	Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease
title_sort	characteristics and application value of ultra-wide-field fundus auto-fluorescence in stargardt disease
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/acf3ec1fe07d4630ab84bebc73e959ab
work_keys_str_mv	AT zhikunzheng characteristicsandapplicationvalueofultrawidefieldfundusautofluorescenceinstargardtdisease AT juanzhang characteristicsandapplicationvalueofultrawidefieldfundusautofluorescenceinstargardtdisease AT huali characteristicsandapplicationvalueofultrawidefieldfundusautofluorescenceinstargardtdisease AT juanjuanli characteristicsandapplicationvalueofultrawidefieldfundusautofluorescenceinstargardtdisease
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Characteristics and application value of ultra-wide-field fundus auto-fluorescence in Stargardt disease

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