Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Tezepelumab and a fusion protein comprising the TSLP r...

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Autores principales:	Kenneth Verstraete, Frank Peelman, Harald Braun, Juan Lopez, Dries Van Rompaey, Ann Dansercoer, Isabel Vandenberghe, Kris Pauwels, Jan Tavernier, Bart N. Lambrecht, Hamida Hammad, Hans De Winter, Rudi Beyaert, Guy Lippens, Savvas N. Savvides
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acf43ca76ac74ec79666eaf28ea442d7
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spelling	oai:doaj.org-article:acf43ca76ac74ec79666eaf28ea442d72021-12-02T15:36:59ZStructure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma10.1038/ncomms149372041-1723https://doaj.org/article/acf43ca76ac74ec79666eaf28ea442d72017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14937https://doaj.org/toc/2041-1723The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Tezepelumab and a fusion protein comprising the TSLP receptors.Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart N. LambrechtHamida HammadHans De WinterRudi BeyaertGuy LippensSavvas N. SavvidesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenneth Verstraete Frank Peelman Harald Braun Juan Lopez Dries Van Rompaey Ann Dansercoer Isabel Vandenberghe Kris Pauwels Jan Tavernier Bart N. Lambrecht Hamida Hammad Hans De Winter Rudi Beyaert Guy Lippens Savvas N. Savvides Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
description	The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is a promising therapeutic target. Here the authors characterize the assembly mechanism of the receptor complex driven by human TSLP, and its antagonism by the monoclonal antibody Tezepelumab and a fusion protein comprising the TSLP receptors.
format	article
author	Kenneth Verstraete Frank Peelman Harald Braun Juan Lopez Dries Van Rompaey Ann Dansercoer Isabel Vandenberghe Kris Pauwels Jan Tavernier Bart N. Lambrecht Hamida Hammad Hans De Winter Rudi Beyaert Guy Lippens Savvas N. Savvides
author_facet	Kenneth Verstraete Frank Peelman Harald Braun Juan Lopez Dries Van Rompaey Ann Dansercoer Isabel Vandenberghe Kris Pauwels Jan Tavernier Bart N. Lambrecht Hamida Hammad Hans De Winter Rudi Beyaert Guy Lippens Savvas N. Savvides
author_sort	Kenneth Verstraete
title	Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
title_short	Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
title_full	Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
title_fullStr	Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
title_full_unstemmed	Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma
title_sort	structure and antagonism of the receptor complex mediated by human tslp in allergy and asthma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/acf43ca76ac74ec79666eaf28ea442d7
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Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

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