Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation...
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Nature Portfolio
2019
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oai:doaj.org-article:acf4f00c9b424b08a7574e6fbe6e3a442021-12-02T14:39:36ZAsymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions10.1038/s41467-019-09904-52041-1723https://doaj.org/article/acf4f00c9b424b08a7574e6fbe6e3a442019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09904-5https://doaj.org/toc/2041-1723Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation reaction of isoquinolines.Qian XiongShunxi DongYushuang ChenXiaohua LiuXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
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Science Q Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
description |
Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation reaction of isoquinolines. |
format |
article |
author |
Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng |
author_facet |
Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng |
author_sort |
Qian Xiong |
title |
Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
title_short |
Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
title_full |
Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
title_fullStr |
Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
title_full_unstemmed |
Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
title_sort |
asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/acf4f00c9b424b08a7574e6fbe6e3a44 |
work_keys_str_mv |
AT qianxiong asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT shunxidong asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT yushuangchen asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT xiaohualiu asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT xiaomingfeng asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions |
_version_ |
1718390553301745664 |