Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation...

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Autores principales:	Qian Xiong, Shunxi Dong, Yushuang Chen, Xiaohua Liu, Xiaoming Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acf4f00c9b424b08a7574e6fbe6e3a44
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spelling	oai:doaj.org-article:acf4f00c9b424b08a7574e6fbe6e3a442021-12-02T14:39:36ZAsymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions10.1038/s41467-019-09904-52041-1723https://doaj.org/article/acf4f00c9b424b08a7574e6fbe6e3a442019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09904-5https://doaj.org/toc/2041-1723Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation reaction of isoquinolines.Qian XiongShunxi DongYushuang ChenXiaohua LiuXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
description	Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation reaction of isoquinolines.
format	article
author	Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng
author_facet	Qian Xiong Shunxi Dong Yushuang Chen Xiaohua Liu Xiaoming Feng
author_sort	Qian Xiong
title	Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
title_short	Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
title_full	Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
title_fullStr	Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
title_full_unstemmed	Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
title_sort	asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/acf4f00c9b424b08a7574e6fbe6e3a44
work_keys_str_mv	AT qianxiong asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT shunxidong asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT yushuangchen asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT xiaohualiu asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions AT xiaomingfeng asymmetricsynthesisoftetrazoleanddihydroisoquinolinederivativesbyisocyanidebasedmulticomponentreactions
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Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

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