Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial

Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for dr...

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Autores principales:	Li-Jin Wang, Lin-Lin Mu, Zi-Xuan Ren, Hua-Jun Tang, Ya-Dong Wei, Wen-Juan Wang, Pei-Pei Song, Lin Zhu, Qiang Ling, He Gao, Lei Zhang, Xun Song, Hua-Feng Wei, Lei-Xin Chang, Tao Wei, Yu-Jing Wang, Wei Zhao, Yan Wang, Lu-Ying Liu, Yi-Ding Zhou, Rui-Dong Zhou, Hua-Shan Xu, Dong-Liang Jiao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	methamphetamine repetitive transcranial magnetic stimulation intermittent theta burst stimulation executive function craving Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/acf50270c5104fb6ab196298bc952755
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spelling	oai:doaj.org-article:acf50270c5104fb6ab196298bc9527552021-12-02T07:52:35ZPredictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial1664-064010.3389/fpsyt.2021.774192https://doaj.org/article/acf50270c5104fb6ab196298bc9527552021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.774192/fullhttps://doaj.org/toc/1664-0640Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for drug use disorder. The purpose of this study was to determine whether executive function helped predict patients' responses to rTMS treatment.Methods: This study employed intermittent theta burst stimulation (iTBS) rTMS modalities and observed their therapeutic effects on executive function and craving in MUD patients. MUD patients from an isolated Drug Rehabilitation Institute in China were chosen and randomly allocated to the iTBS group and sham-stimulation group. All participants underwent the Behavior Rating Inventory of Executive Function - Adult Version Scale (BRIEF-A) and Visual Analog Scales (VAS) measurements. Sixty-five healthy adults matched to the general condition of MUD patients were also recruited as healthy controls.Findings: Patients with MUD had significantly worse executive function. iTBS groups had better treatment effects on the MUD group than the sham-stimulation group. Further Spearman rank correlation and stepwise multivariate regression analysis revealed that reduction rates of the total score of the BRIEF-A and subscale scores of the inhibition factor and working memory factor in the iTBS group positively correlated with improvements in craving. ROC curve analysis showed that working memory (AUC = 87.4%; 95% CI = 0.220, 0.631) and GEC (AUC = 0.761%; 95% CI = 0.209, 0.659) had predictive power to iTBS therapeutic efficacy. The cutoff values are 13.393 and 59.804, respectively.Conclusions: The iTBS rTMS had a better therapeutic effect on the executive function of patients with MUD, and the improved executive function had the potential to become a predictor for the efficacy of iTBS modality for MUD treatment.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR2100046954.Li-Jin WangLin-Lin MuZi-Xuan RenHua-Jun TangYa-Dong WeiWen-Juan WangPei-Pei SongLin ZhuQiang LingHe GaoLei ZhangXun SongHua-Feng WeiLei-Xin ChangTao WeiYu-Jing WangWei ZhaoYan WangLu-Ying LiuYi-Ding ZhouRui-Dong ZhouHua-Shan XuDong-Liang JiaoFrontiers Media S.A.articlemethamphetaminerepetitive transcranial magnetic stimulationintermittent theta burst stimulationexecutive functioncravingPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	methamphetamine repetitive transcranial magnetic stimulation intermittent theta burst stimulation executive function craving Psychiatry RC435-571
spellingShingle	methamphetamine repetitive transcranial magnetic stimulation intermittent theta burst stimulation executive function craving Psychiatry RC435-571 Li-Jin Wang Lin-Lin Mu Zi-Xuan Ren Hua-Jun Tang Ya-Dong Wei Wen-Juan Wang Pei-Pei Song Lin Zhu Qiang Ling He Gao Lei Zhang Xun Song Hua-Feng Wei Lei-Xin Chang Tao Wei Yu-Jing Wang Wei Zhao Yan Wang Lu-Ying Liu Yi-Ding Zhou Rui-Dong Zhou Hua-Shan Xu Dong-Liang Jiao Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
description	Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for drug use disorder. The purpose of this study was to determine whether executive function helped predict patients' responses to rTMS treatment.Methods: This study employed intermittent theta burst stimulation (iTBS) rTMS modalities and observed their therapeutic effects on executive function and craving in MUD patients. MUD patients from an isolated Drug Rehabilitation Institute in China were chosen and randomly allocated to the iTBS group and sham-stimulation group. All participants underwent the Behavior Rating Inventory of Executive Function - Adult Version Scale (BRIEF-A) and Visual Analog Scales (VAS) measurements. Sixty-five healthy adults matched to the general condition of MUD patients were also recruited as healthy controls.Findings: Patients with MUD had significantly worse executive function. iTBS groups had better treatment effects on the MUD group than the sham-stimulation group. Further Spearman rank correlation and stepwise multivariate regression analysis revealed that reduction rates of the total score of the BRIEF-A and subscale scores of the inhibition factor and working memory factor in the iTBS group positively correlated with improvements in craving. ROC curve analysis showed that working memory (AUC = 87.4%; 95% CI = 0.220, 0.631) and GEC (AUC = 0.761%; 95% CI = 0.209, 0.659) had predictive power to iTBS therapeutic efficacy. The cutoff values are 13.393 and 59.804, respectively.Conclusions: The iTBS rTMS had a better therapeutic effect on the executive function of patients with MUD, and the improved executive function had the potential to become a predictor for the efficacy of iTBS modality for MUD treatment.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR2100046954.
format	article
author	Li-Jin Wang Lin-Lin Mu Zi-Xuan Ren Hua-Jun Tang Ya-Dong Wei Wen-Juan Wang Pei-Pei Song Lin Zhu Qiang Ling He Gao Lei Zhang Xun Song Hua-Feng Wei Lei-Xin Chang Tao Wei Yu-Jing Wang Wei Zhao Yan Wang Lu-Ying Liu Yi-Ding Zhou Rui-Dong Zhou Hua-Shan Xu Dong-Liang Jiao
author_facet	Li-Jin Wang Lin-Lin Mu Zi-Xuan Ren Hua-Jun Tang Ya-Dong Wei Wen-Juan Wang Pei-Pei Song Lin Zhu Qiang Ling He Gao Lei Zhang Xun Song Hua-Feng Wei Lei-Xin Chang Tao Wei Yu-Jing Wang Wei Zhao Yan Wang Lu-Ying Liu Yi-Ding Zhou Rui-Dong Zhou Hua-Shan Xu Dong-Liang Jiao
author_sort	Li-Jin Wang
title	Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
title_short	Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
title_full	Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
title_fullStr	Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
title_full_unstemmed	Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial
title_sort	predictive role of executive function in the efficacy of intermittent theta burst transcranial magnetic stimulation modalities for treating methamphetamine use disorder—a randomized clinical trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/acf50270c5104fb6ab196298bc952755
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Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial

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