Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation

Abstract Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however, whether inhibitory neural activity occu...

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Autores principales:	Toshiyuki Aoyama, Fuminari Kaneko, Yukari Ohashi, Yutaka Kohno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acf62baaac88445395b6931ddc0dfa17
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spelling	oai:doaj.org-article:acf62baaac88445395b6931ddc0dfa172021-12-02T15:07:55ZDissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation10.1038/s41598-019-49456-82045-2322https://doaj.org/article/acf62baaac88445395b6931ddc0dfa172019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49456-8https://doaj.org/toc/2045-2322Abstract Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however, whether inhibitory neural activity occurs during MI remains unknown. In addition, recent studies have demonstrated that a combined MI and action observation (MI + AO) produces strong neurophysiological changes compared with MI or AO alone. Therefore, we investigated inhibitory changes in cortical and spinal excitability of the antagonist muscle during MI + AO and ME. Single-pulse transcranial magnetic stimulation (TMS) experiments revealed that corticospinal excitability of the antagonist muscle was decreased during MI + AO. Conversely, F-wave experiments showed that F-wave persistence of the antagonist muscle increased. Paired-pulse TMS experiment also demonstrated that short-interval intracortical inhibition (SICI) did not contribute to this inhibition. Therefore, cortical mediated inhibition, except for SICI, may be related to this inhibition. Conversely, such clear inhibition of the antagonist muscle was not observed during ME, presumably owing to the effects of muscle contraction to decelerate the movements and/or sensory input accompanying the joint movements. These findings provide important insights into the neurophysiological differences between MI + AO and ME.Toshiyuki AoyamaFuminari KanekoYukari OhashiYutaka KohnoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshiyuki Aoyama Fuminari Kaneko Yukari Ohashi Yutaka Kohno Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
description	Abstract Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however, whether inhibitory neural activity occurs during MI remains unknown. In addition, recent studies have demonstrated that a combined MI and action observation (MI + AO) produces strong neurophysiological changes compared with MI or AO alone. Therefore, we investigated inhibitory changes in cortical and spinal excitability of the antagonist muscle during MI + AO and ME. Single-pulse transcranial magnetic stimulation (TMS) experiments revealed that corticospinal excitability of the antagonist muscle was decreased during MI + AO. Conversely, F-wave experiments showed that F-wave persistence of the antagonist muscle increased. Paired-pulse TMS experiment also demonstrated that short-interval intracortical inhibition (SICI) did not contribute to this inhibition. Therefore, cortical mediated inhibition, except for SICI, may be related to this inhibition. Conversely, such clear inhibition of the antagonist muscle was not observed during ME, presumably owing to the effects of muscle contraction to decelerate the movements and/or sensory input accompanying the joint movements. These findings provide important insights into the neurophysiological differences between MI + AO and ME.
format	article
author	Toshiyuki Aoyama Fuminari Kaneko Yukari Ohashi Yutaka Kohno
author_facet	Toshiyuki Aoyama Fuminari Kaneko Yukari Ohashi Yutaka Kohno
author_sort	Toshiyuki Aoyama
title	Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
title_short	Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
title_full	Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
title_fullStr	Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
title_full_unstemmed	Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
title_sort	dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/acf62baaac88445395b6931ddc0dfa17
work_keys_str_mv	AT toshiyukiaoyama dissociationbetweencorticalandspinalexcitabilityoftheantagonistmuscleduringcombinedmotorimageryandactionobservation AT fuminarikaneko dissociationbetweencorticalandspinalexcitabilityoftheantagonistmuscleduringcombinedmotorimageryandactionobservation AT yukariohashi dissociationbetweencorticalandspinalexcitabilityoftheantagonistmuscleduringcombinedmotorimageryandactionobservation AT yutakakohno dissociationbetweencorticalandspinalexcitabilityoftheantagonistmuscleduringcombinedmotorimageryandactionobservation
_version_	1718388339672875008

Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation

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