SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.

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Detalles Bibliográficos
Autores principales: Seiya Ozono, Yanzhao Zhang, Hirotaka Ode, Kaori Sano, Toong Seng Tan, Kazuo Imai, Kazuyasu Miyoshi, Satoshi Kishigami, Takamasa Ueno, Yasumasa Iwatani, Tadaki Suzuki, Kenzo Tokunaga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/acf66950162a40c68bcc2ed12d14299c
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Descripción
Sumario:SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.

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