SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.

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Autores principales:	Seiya Ozono, Yanzhao Zhang, Hirotaka Ode, Kaori Sano, Toong Seng Tan, Kazuo Imai, Kazuyasu Miyoshi, Satoshi Kishigami, Takamasa Ueno, Yasumasa Iwatani, Tadaki Suzuki, Kenzo Tokunaga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acf66950162a40c68bcc2ed12d14299c
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spelling	oai:doaj.org-article:acf66950162a40c68bcc2ed12d14299c2021-12-02T13:30:07ZSARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity10.1038/s41467-021-21118-22041-1723https://doaj.org/article/acf66950162a40c68bcc2ed12d14299c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21118-2https://doaj.org/toc/2041-1723SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.Seiya OzonoYanzhao ZhangHirotaka OdeKaori SanoToong Seng TanKazuo ImaiKazuyasu MiyoshiSatoshi KishigamiTakamasa UenoYasumasa IwataniTadaki SuzukiKenzo TokunagaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seiya Ozono Yanzhao Zhang Hirotaka Ode Kaori Sano Toong Seng Tan Kazuo Imai Kazuyasu Miyoshi Satoshi Kishigami Takamasa Ueno Yasumasa Iwatani Tadaki Suzuki Kenzo Tokunaga SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
description	SARS-CoV-2 D614G spike protein mutation is one of the predominant circulating vital mutants. Here, Ozono et al. demonstrate that D614G mutation increases in vitro cell entry by acquiring higher affinity to ACE2.
format	article
author	Seiya Ozono Yanzhao Zhang Hirotaka Ode Kaori Sano Toong Seng Tan Kazuo Imai Kazuyasu Miyoshi Satoshi Kishigami Takamasa Ueno Yasumasa Iwatani Tadaki Suzuki Kenzo Tokunaga
author_facet	Seiya Ozono Yanzhao Zhang Hirotaka Ode Kaori Sano Toong Seng Tan Kazuo Imai Kazuyasu Miyoshi Satoshi Kishigami Takamasa Ueno Yasumasa Iwatani Tadaki Suzuki Kenzo Tokunaga
author_sort	Seiya Ozono
title	SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
title_short	SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
title_full	SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
title_fullStr	SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
title_full_unstemmed	SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
title_sort	sars-cov-2 d614g spike mutation increases entry efficiency with enhanced ace2-binding affinity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acf66950162a40c68bcc2ed12d14299c
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SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

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