Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants

Here, the authors report a genome-wide association analysis for corneal resistance factor (CRF), a measure of corneal biomechanical properties relevant to a number of corneal diseases. They identify 135 loci associated with CRF and use fine-mapping and ATAC-seq in human cornea cell lines to identify...

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Autores principales:	Xinyi Jiang, Nefeli Dellepiane, Erola Pairo-Castineira, Thibaud Boutin, Yatendra Kumar, Wendy A. Bickmore, Veronique Vitart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/acf6f0549b5e4be2b8d0c1d371bee340
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spelling	oai:doaj.org-article:acf6f0549b5e4be2b8d0c1d371bee3402021-12-02T11:43:43ZFine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants10.1038/s42003-020-01497-w2399-3642https://doaj.org/article/acf6f0549b5e4be2b8d0c1d371bee3402020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01497-whttps://doaj.org/toc/2399-3642Here, the authors report a genome-wide association analysis for corneal resistance factor (CRF), a measure of corneal biomechanical properties relevant to a number of corneal diseases. They identify 135 loci associated with CRF and use fine-mapping and ATAC-seq in human cornea cell lines to identify putative causal variants affecting gene expression.Xinyi JiangNefeli DellepianeErola Pairo-CastineiraThibaud BoutinYatendra KumarWendy A. BickmoreVeronique VitartNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xinyi Jiang Nefeli Dellepiane Erola Pairo-Castineira Thibaud Boutin Yatendra Kumar Wendy A. Bickmore Veronique Vitart Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
description	Here, the authors report a genome-wide association analysis for corneal resistance factor (CRF), a measure of corneal biomechanical properties relevant to a number of corneal diseases. They identify 135 loci associated with CRF and use fine-mapping and ATAC-seq in human cornea cell lines to identify putative causal variants affecting gene expression.
format	article
author	Xinyi Jiang Nefeli Dellepiane Erola Pairo-Castineira Thibaud Boutin Yatendra Kumar Wendy A. Bickmore Veronique Vitart
author_facet	Xinyi Jiang Nefeli Dellepiane Erola Pairo-Castineira Thibaud Boutin Yatendra Kumar Wendy A. Bickmore Veronique Vitart
author_sort	Xinyi Jiang
title	Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
title_short	Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
title_full	Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
title_fullStr	Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
title_full_unstemmed	Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
title_sort	fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/acf6f0549b5e4be2b8d0c1d371bee340
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Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants

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