Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, identify the SLA-binding site on NS5, and propose models...

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Autores principales:	Eunhye Lee, Paul J. Bujalowski, Tadahisa Teramoto, Keerthi Gottipati, Seth D. Scott, Radhakrishnan Padmanabhan, Kyung H. Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/acf8de90f3514ec8ab19ff937e51ff75
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spelling	oai:doaj.org-article:acf8de90f3514ec8ab19ff937e51ff752021-12-02T15:37:56ZStructures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase10.1038/s41467-021-22846-12041-1723https://doaj.org/article/acf8de90f3514ec8ab19ff937e51ff752021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22846-1https://doaj.org/toc/2041-1723Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, identify the SLA-binding site on NS5, and propose models for how NS5 recognizes the RNA promoter.Eunhye LeePaul J. BujalowskiTadahisa TeramotoKeerthi GottipatiSeth D. ScottRadhakrishnan PadmanabhanKyung H. ChoiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eunhye Lee Paul J. Bujalowski Tadahisa Teramoto Keerthi Gottipati Seth D. Scott Radhakrishnan Padmanabhan Kyung H. Choi Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
description	Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5’ end of the RNA genome as a promoter for RNA synthesis by the viral polymerase NS5. Here the authors describe the structures of dengue and Zika virus SLAs, identify the SLA-binding site on NS5, and propose models for how NS5 recognizes the RNA promoter.
format	article
author	Eunhye Lee Paul J. Bujalowski Tadahisa Teramoto Keerthi Gottipati Seth D. Scott Radhakrishnan Padmanabhan Kyung H. Choi
author_facet	Eunhye Lee Paul J. Bujalowski Tadahisa Teramoto Keerthi Gottipati Seth D. Scott Radhakrishnan Padmanabhan Kyung H. Choi
author_sort	Eunhye Lee
title	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
title_short	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
title_full	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
title_fullStr	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
title_full_unstemmed	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase
title_sort	structures of flavivirus rna promoters suggest two binding modes with ns5 polymerase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acf8de90f3514ec8ab19ff937e51ff75
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Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

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