Additive and interaction effects of working memory and motor sequence training on brain functional connectivity

Abstract Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced...

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Autores principales:	Priska Zuber, Laura Gaetano, Alessandra Griffa, Manuel Huerbin, Ludovico Pedullà, Laura Bonzano, Anna Altermatt, Charidimos Tsagkas, Katrin Parmar, Patric Hagmann, Jens Wuerfel, Ludwig Kappos, Till Sprenger, Olaf Sporns, Stefano Magon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acf989ab70b14b12a81ae41a7568a63e
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spelling	oai:doaj.org-article:acf989ab70b14b12a81ae41a7568a63e2021-12-05T12:16:04ZAdditive and interaction effects of working memory and motor sequence training on brain functional connectivity10.1038/s41598-021-02492-92045-2322https://doaj.org/article/acf989ab70b14b12a81ae41a7568a63e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02492-9https://doaj.org/toc/2045-2322Abstract Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced by sequential (WM + MSL and MSL + WM) and combined (WM × MSL) training programs. 54 healthy subjects (27 women; mean age: 30.2 ± 8.6 years) allocated to three training groups underwent twenty-four 40-min training sessions over 6 weeks and four cognitive assessments including functional MRI. A double-baseline approach was applied to account for practice effects. Test performances were compared using linear mixed-effects models and t-tests. Resting state fMRI data were analysed using FSL. Processing speed, verbal WM and manual dexterity increased following training in all groups. MSL + WM training led to additive effects in processing speed and verbal WM. Increased FC was found after training in a network including the right angular gyrus, left superior temporal sulcus, right superior parietal gyrus, bilateral middle temporal gyri and left precentral gyrus. No difference in FC was found between double baselines. Results indicate distinct patterns of resting state FC modulation related to sequential and combined WM and MSL training suggesting a relevance of the order of training performance. These observations could provide new insight for the planning of effective training/rehabilitation.Priska ZuberLaura GaetanoAlessandra GriffaManuel HuerbinLudovico PedullàLaura BonzanoAnna AltermattCharidimos TsagkasKatrin ParmarPatric HagmannJens WuerfelLudwig KapposTill SprengerOlaf SpornsStefano MagonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Priska Zuber Laura Gaetano Alessandra Griffa Manuel Huerbin Ludovico Pedullà Laura Bonzano Anna Altermatt Charidimos Tsagkas Katrin Parmar Patric Hagmann Jens Wuerfel Ludwig Kappos Till Sprenger Olaf Sporns Stefano Magon Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
description	Abstract Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced by sequential (WM + MSL and MSL + WM) and combined (WM × MSL) training programs. 54 healthy subjects (27 women; mean age: 30.2 ± 8.6 years) allocated to three training groups underwent twenty-four 40-min training sessions over 6 weeks and four cognitive assessments including functional MRI. A double-baseline approach was applied to account for practice effects. Test performances were compared using linear mixed-effects models and t-tests. Resting state fMRI data were analysed using FSL. Processing speed, verbal WM and manual dexterity increased following training in all groups. MSL + WM training led to additive effects in processing speed and verbal WM. Increased FC was found after training in a network including the right angular gyrus, left superior temporal sulcus, right superior parietal gyrus, bilateral middle temporal gyri and left precentral gyrus. No difference in FC was found between double baselines. Results indicate distinct patterns of resting state FC modulation related to sequential and combined WM and MSL training suggesting a relevance of the order of training performance. These observations could provide new insight for the planning of effective training/rehabilitation.
format	article
author	Priska Zuber Laura Gaetano Alessandra Griffa Manuel Huerbin Ludovico Pedullà Laura Bonzano Anna Altermatt Charidimos Tsagkas Katrin Parmar Patric Hagmann Jens Wuerfel Ludwig Kappos Till Sprenger Olaf Sporns Stefano Magon
author_facet	Priska Zuber Laura Gaetano Alessandra Griffa Manuel Huerbin Ludovico Pedullà Laura Bonzano Anna Altermatt Charidimos Tsagkas Katrin Parmar Patric Hagmann Jens Wuerfel Ludwig Kappos Till Sprenger Olaf Sporns Stefano Magon
author_sort	Priska Zuber
title	Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
title_short	Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
title_full	Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
title_fullStr	Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
title_full_unstemmed	Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
title_sort	additive and interaction effects of working memory and motor sequence training on brain functional connectivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acf989ab70b14b12a81ae41a7568a63e
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Additive and interaction effects of working memory and motor sequence training on brain functional connectivity

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