The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits

This study investigates the effect of Ubiquinone and/or calcium carbonate (CaCO3) on bone mineral density (BMD) in rabbits at the healing site in mandibular bone postoperatively. Sixty healthy white male New Zealand rabbits (almost the same age [5-6 months], weight [2.0±0.25 kg] and circumstance) we...

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Autores principales:	Ahmed A. Hussein, Ghada A. Taqa
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2021
Materias:	bone healing bone mineral density caco3 rabbits ubiquinone Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2021.87062.1091 https://doaj.org/article/acff2b9f891243cbbbf96e882b068c25
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spelling	oai:doaj.org-article:acff2b9f891243cbbbf96e882b068c252021-12-02T16:59:36ZThe Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbitshttps://dx.doi.org/10.21608/javs.2021.87062.10911687-40722090-3308https://doaj.org/article/acff2b9f891243cbbbf96e882b068c252021-10-01T00:00:00Zhttps://javs.journals.ekb.eg/article_191007.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308This study investigates the effect of Ubiquinone and/or calcium carbonate (CaCO3) on bone mineral density (BMD) in rabbits at the healing site in mandibular bone postoperatively. Sixty healthy white male New Zealand rabbits (almost the same age [5-6 months], weight [2.0±0.25 kg] and circumstance) were used in this study. The heavy-duty dental engine drilled a mandibular groove of 2mm diameter and 6mm length in all animals. Post-surgery, the rabbits were randomly divided into six groups (10 each) according to the treatment. According to the evaluation period, each group was further subdivided into two subgroups (5 rabbits each); 15 and 30 days. The groups included; control group (the groove was not filled by anything) and treated groups which included five groups as follows: group I (in which the groove was filled with Ubiquinone), group II (groove was filled with CaCO3), group III (groove was filled with CaCO3: Ubiquinone as a ratio [1:1]), group IV ( groove was filled with CaCO3: Ubiquinone as a ratio [1:2]) and group V (groove was filled with CaCO3: Ubiquinone as a ratio [2:1]). The BMD was measured using Densitometry after 15 and 30 days. Statistical analysis showed significant differences at p≤0.05 in bone mineral density (BMD) between the control group (92±0.15) and all other treated groups except group III (125±3.54) and group IV (126±5.13) showed no significant differences at follow-up times at 15 days. Also, in the present study, we found there is a significant difference in bone mineral density among the control group (109±1.25), group I (144±3.45), group II (153±6.24) and group V (182±12.56) groups respectively. ANOVA test showed no significant difference in group III (160±8.94) and group IV (165±9.11) at follow-up times at 30 days. Adding the Ubiquinone and/or CaCO3 showed a significant increase in BMD manifested by bone healing like space-filling, newly formed bone trabeculae and a high number of lacunas compared with the control group. It can be concluded that, the Addition of Ubiquinone and/or CaCO3 to the mandibular fracture has a favourable effect on BMD and enhance bone healing in rabbits. Ahmed A. HusseinGhada A. TaqaEgyptian Society for Animal Managementarticlebone healingbone mineral densitycaco3rabbitsubiquinoneZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 6, Iss 4, Pp 15-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone healing bone mineral density caco3 rabbits ubiquinone Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	bone healing bone mineral density caco3 rabbits ubiquinone Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Ahmed A. Hussein Ghada A. Taqa The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
description	This study investigates the effect of Ubiquinone and/or calcium carbonate (CaCO3) on bone mineral density (BMD) in rabbits at the healing site in mandibular bone postoperatively. Sixty healthy white male New Zealand rabbits (almost the same age [5-6 months], weight [2.0±0.25 kg] and circumstance) were used in this study. The heavy-duty dental engine drilled a mandibular groove of 2mm diameter and 6mm length in all animals. Post-surgery, the rabbits were randomly divided into six groups (10 each) according to the treatment. According to the evaluation period, each group was further subdivided into two subgroups (5 rabbits each); 15 and 30 days. The groups included; control group (the groove was not filled by anything) and treated groups which included five groups as follows: group I (in which the groove was filled with Ubiquinone), group II (groove was filled with CaCO3), group III (groove was filled with CaCO3: Ubiquinone as a ratio [1:1]), group IV ( groove was filled with CaCO3: Ubiquinone as a ratio [1:2]) and group V (groove was filled with CaCO3: Ubiquinone as a ratio [2:1]). The BMD was measured using Densitometry after 15 and 30 days. Statistical analysis showed significant differences at p≤0.05 in bone mineral density (BMD) between the control group (92±0.15) and all other treated groups except group III (125±3.54) and group IV (126±5.13) showed no significant differences at follow-up times at 15 days. Also, in the present study, we found there is a significant difference in bone mineral density among the control group (109±1.25), group I (144±3.45), group II (153±6.24) and group V (182±12.56) groups respectively. ANOVA test showed no significant difference in group III (160±8.94) and group IV (165±9.11) at follow-up times at 30 days. Adding the Ubiquinone and/or CaCO3 showed a significant increase in BMD manifested by bone healing like space-filling, newly formed bone trabeculae and a high number of lacunas compared with the control group. It can be concluded that, the Addition of Ubiquinone and/or CaCO3 to the mandibular fracture has a favourable effect on BMD and enhance bone healing in rabbits.
format	article
author	Ahmed A. Hussein Ghada A. Taqa
author_facet	Ahmed A. Hussein Ghada A. Taqa
author_sort	Ahmed A. Hussein
title	The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
title_short	The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
title_full	The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
title_fullStr	The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
title_full_unstemmed	The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits
title_sort	impact of natural calcium carbonate and ubiquinone on bone mineral density in rabbits
publisher	Egyptian Society for Animal Management
publishDate	2021
url	https://dx.doi.org/10.21608/javs.2021.87062.1091 https://doaj.org/article/acff2b9f891243cbbbf96e882b068c25
work_keys_str_mv	AT ahmedahussein theimpactofnaturalcalciumcarbonateandubiquinoneonbonemineraldensityinrabbits AT ghadaataqa theimpactofnaturalcalciumcarbonateandubiquinoneonbonemineraldensityinrabbits AT ahmedahussein impactofnaturalcalciumcarbonateandubiquinoneonbonemineraldensityinrabbits AT ghadaataqa impactofnaturalcalciumcarbonateandubiquinoneonbonemineraldensityinrabbits
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The Impact of Natural Calcium Carbonate and Ubiquinone on Bone Mineral Density in Rabbits

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