Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty

Abstract The aim of this study was to compare aqueous humour (AqH) cytokine profiles before and after Descemet’s membrane endothelial keratoplasty (DMEK) in eyes with bullous keratopathy (BK) and age-matched normal eyes. A total of 49 participants (mean age 75.0 ± 13.5 years) were divided into three...

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Autores principales:	Takahiko Hayashi, Hidenori Takahashi, Satoru Inoda, Toshiki Shimizu, Akira Kobayashi, Hidetoshi Kawashima, Takefumi Yamaguchi, Satoru Yamagami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/acff2dea85ad420b970a30de198fc1fc
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spelling	oai:doaj.org-article:acff2dea85ad420b970a30de198fc1fc2021-12-02T18:53:19ZAqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty10.1038/s41598-021-96566-32045-2322https://doaj.org/article/acff2dea85ad420b970a30de198fc1fc2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96566-3https://doaj.org/toc/2045-2322Abstract The aim of this study was to compare aqueous humour (AqH) cytokine profiles before and after Descemet’s membrane endothelial keratoplasty (DMEK) in eyes with bullous keratopathy (BK) and age-matched normal eyes. A total of 49 participants (mean age 75.0 ± 13.5 years) were divided into three groups: (1) BK patients scheduled for DMEK (BK group); (2) patients after DMEK (DMEK group; average postoperative time 1,018 ± 460 days); and (3) control participants without corneal endothelial disease scheduled for cataract surgery (control group). AqH (0.2 mL) was collected from all participants, and the levels of various AqH cytokines were simultaneously measured using a multiplex bead immunoassay. The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1β, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group. In addition, the levels of IL-1β and IL-5 were significantly lower in the DMEK group than in the control group. The AqH levels of several pro-inflammatory cytokines were significantly reduced after DMEK, indicating that regeneration of the endothelial pump owing to the transplantation of a healthy endothelium might have a positive effect on anterior chamber inflammation.Takahiko HayashiHidenori TakahashiSatoru InodaToshiki ShimizuAkira KobayashiHidetoshi KawashimaTakefumi YamaguchiSatoru YamagamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takahiko Hayashi Hidenori Takahashi Satoru Inoda Toshiki Shimizu Akira Kobayashi Hidetoshi Kawashima Takefumi Yamaguchi Satoru Yamagami Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
description	Abstract The aim of this study was to compare aqueous humour (AqH) cytokine profiles before and after Descemet’s membrane endothelial keratoplasty (DMEK) in eyes with bullous keratopathy (BK) and age-matched normal eyes. A total of 49 participants (mean age 75.0 ± 13.5 years) were divided into three groups: (1) BK patients scheduled for DMEK (BK group); (2) patients after DMEK (DMEK group; average postoperative time 1,018 ± 460 days); and (3) control participants without corneal endothelial disease scheduled for cataract surgery (control group). AqH (0.2 mL) was collected from all participants, and the levels of various AqH cytokines were simultaneously measured using a multiplex bead immunoassay. The DMEK group exhibited significantly lower concentrations of several pro-inflammatory cytokines, such as IL-1β, IL-5, IL-6, IL-10, and IL-8, and granulocyte colony stimulating factor than the BK group. In addition, the levels of IL-1β and IL-5 were significantly lower in the DMEK group than in the control group. The AqH levels of several pro-inflammatory cytokines were significantly reduced after DMEK, indicating that regeneration of the endothelial pump owing to the transplantation of a healthy endothelium might have a positive effect on anterior chamber inflammation.
format	article
author	Takahiko Hayashi Hidenori Takahashi Satoru Inoda Toshiki Shimizu Akira Kobayashi Hidetoshi Kawashima Takefumi Yamaguchi Satoru Yamagami
author_facet	Takahiko Hayashi Hidenori Takahashi Satoru Inoda Toshiki Shimizu Akira Kobayashi Hidetoshi Kawashima Takefumi Yamaguchi Satoru Yamagami
author_sort	Takahiko Hayashi
title	Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
title_short	Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
title_full	Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
title_fullStr	Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
title_full_unstemmed	Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty
title_sort	aqueous humour cytokine profiles after descemet’s membrane endothelial keratoplasty
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/acff2dea85ad420b970a30de198fc1fc
work_keys_str_mv	AT takahikohayashi aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT hidenoritakahashi aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT satoruinoda aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT toshikishimizu aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT akirakobayashi aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT hidetoshikawashima aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT takefumiyamaguchi aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty AT satoruyamagami aqueoushumourcytokineprofilesafterdescemetsmembraneendothelialkeratoplasty
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Aqueous humour cytokine profiles after Descemet’s membrane endothelial keratoplasty

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