Glycemic control and anti-osteopathic effect of propolis in diabetic rats

M Al-Hariri, T Gamal Eldin, B Abu-Hozaifa, A ElnourDepartment of Physiology, College of Medicine, University of Dammam, Dammam, Saudi ArabiaAbstract: The aim of the study was to explore the possibility that propolis can control diabetes mellitus and prevent diabetic osteopathy in rats. The study com...

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Autores principales:	Al-Hariri M,&nbsp;Gamal Eldin T, Abu-Hozaifa B, Elnour A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ad04448d6c2a4e0b902782e87f880450
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spelling	oai:doaj.org-article:ad04448d6c2a4e0b902782e87f8804502021-12-02T05:20:42ZGlycemic control and anti-osteopathic effect of propolis in diabetic rats1178-7007https://doaj.org/article/ad04448d6c2a4e0b902782e87f8804502011-11-01T00:00:00Zhttp://www.dovepress.com/glycemic-control-and-anti-osteopathic-effect-of-propolis-in-diabetic-r-a8708https://doaj.org/toc/1178-7007M Al-Hariri, T Gamal Eldin, B Abu-Hozaifa, A ElnourDepartment of Physiology, College of Medicine, University of Dammam, Dammam, Saudi ArabiaAbstract: The aim of the study was to explore the possibility that propolis can control diabetes mellitus and prevent diabetic osteopathy in rats. The study compared 60 streptozotocin (STZ)-induced diabetic rats, with ten nondiabetic rats used as a negative control. The experimental design comprised seven groups (n = 10 rats per group): (1) nondiabetic, used as a negative control; (2) nontreated, used as a positive control; (3) treated with insulin alone; (4) treated with a single dose of propolis alone; (5) treated with a double dose of propolis; (6) treated with insulin and a single dose of propolis; and (7) treated with insulin and a double dose of propolis. After 6 weeks of treatment, the rats were sacrificed. Ratios of femur ash to femur weight and of femur weight to body weight (FW/BW) were calculated and calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations in femur ash were estimated and analyzed. Fasting blood glucose (FBG), plasma insulin and glucagon, serum thiobarbituric acid reactive substances (TBARS), plasma parathyroid hormone (PTH), and calcitonin levels were also estimated and analyzed. There was significant reduction in FBG in all diabetic treated rats. Similarly, higher plasma insulin levels were observed in diabetic rats treated with propolis and insulin than in nontreated diabetic rats, although plasma insulin was not comparatively higher in diabetic rats treated with insulin alone. Serum TBARS was significantly lower in the propolis treated rats than the diabetic nontreated rats. No differences in PTH and calcitonin levels were observed among treatment groups. The FW/BW ratio was significantly higher in diabetic treated groups than in control groups. Furthermore, diabetic rats treated with propolis and insulin had significantly higher Ca, P, and Mg concentrations in femoral ash than nontreated diabetic rats and diabetic rats treated with insulin alone. In conclusion, propolis has a remarkable effect on glucose homeostasis and bone mineralization.Keywords: diabetes mellitus, osteopathy, streptozotocin, insulinAl-Hariri M,&nbsp;Gamal Eldin TAbu-Hozaifa BElnour ADove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2011, Iss default, Pp 377-384 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Al-Hariri M,&nbsp;Gamal Eldin T Abu-Hozaifa B Elnour A Glycemic control and anti-osteopathic effect of propolis in diabetic rats
description	M Al-Hariri, T Gamal Eldin, B Abu-Hozaifa, A ElnourDepartment of Physiology, College of Medicine, University of Dammam, Dammam, Saudi ArabiaAbstract: The aim of the study was to explore the possibility that propolis can control diabetes mellitus and prevent diabetic osteopathy in rats. The study compared 60 streptozotocin (STZ)-induced diabetic rats, with ten nondiabetic rats used as a negative control. The experimental design comprised seven groups (n = 10 rats per group): (1) nondiabetic, used as a negative control; (2) nontreated, used as a positive control; (3) treated with insulin alone; (4) treated with a single dose of propolis alone; (5) treated with a double dose of propolis; (6) treated with insulin and a single dose of propolis; and (7) treated with insulin and a double dose of propolis. After 6 weeks of treatment, the rats were sacrificed. Ratios of femur ash to femur weight and of femur weight to body weight (FW/BW) were calculated and calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations in femur ash were estimated and analyzed. Fasting blood glucose (FBG), plasma insulin and glucagon, serum thiobarbituric acid reactive substances (TBARS), plasma parathyroid hormone (PTH), and calcitonin levels were also estimated and analyzed. There was significant reduction in FBG in all diabetic treated rats. Similarly, higher plasma insulin levels were observed in diabetic rats treated with propolis and insulin than in nontreated diabetic rats, although plasma insulin was not comparatively higher in diabetic rats treated with insulin alone. Serum TBARS was significantly lower in the propolis treated rats than the diabetic nontreated rats. No differences in PTH and calcitonin levels were observed among treatment groups. The FW/BW ratio was significantly higher in diabetic treated groups than in control groups. Furthermore, diabetic rats treated with propolis and insulin had significantly higher Ca, P, and Mg concentrations in femoral ash than nontreated diabetic rats and diabetic rats treated with insulin alone. In conclusion, propolis has a remarkable effect on glucose homeostasis and bone mineralization.Keywords: diabetes mellitus, osteopathy, streptozotocin, insulin
format	article
author	Al-Hariri M,&nbsp;Gamal Eldin T Abu-Hozaifa B Elnour A
author_facet	Al-Hariri M,&nbsp;Gamal Eldin T Abu-Hozaifa B Elnour A
author_sort	Al-Hariri M,&nbsp;Gamal Eldin T
title	Glycemic control and anti-osteopathic effect of propolis in diabetic rats
title_short	Glycemic control and anti-osteopathic effect of propolis in diabetic rats
title_full	Glycemic control and anti-osteopathic effect of propolis in diabetic rats
title_fullStr	Glycemic control and anti-osteopathic effect of propolis in diabetic rats
title_full_unstemmed	Glycemic control and anti-osteopathic effect of propolis in diabetic rats
title_sort	glycemic control and anti-osteopathic effect of propolis in diabetic rats
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/ad04448d6c2a4e0b902782e87f880450
work_keys_str_mv	AT alharirimampnbspgamaleldint glycemiccontrolandantiosteopathiceffectofpropolisindiabeticrats AT abuhozaifab glycemiccontrolandantiosteopathiceffectofpropolisindiabeticrats AT elnoura glycemiccontrolandantiosteopathiceffectofpropolisindiabeticrats
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Glycemic control and anti-osteopathic effect of propolis in diabetic rats

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