ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.

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Autores principales:	Amir Ata Saei, Christian Michel Beusch, Alexey Chernobrovkin, Pierre Sabatier, Bo Zhang, Ülkü Güler Tokat, Eleni Stergiou, Massimiliano Gaetani, Ákos Végvári, Roman A. Zubarev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad0814e6df26497b89b780d2b504f842
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spelling	oai:doaj.org-article:ad0814e6df26497b89b780d2b504f8422021-12-02T17:01:29ZProTargetMiner as a proteome signature library of anticancer molecules for functional discovery10.1038/s41467-019-13582-82041-1723https://doaj.org/article/ad0814e6df26497b89b780d2b504f8422019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13582-8https://doaj.org/toc/2041-1723Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.Amir Ata SaeiChristian Michel BeuschAlexey ChernobrovkinPierre SabatierBo ZhangÜlkü Güler TokatEleni StergiouMassimiliano GaetaniÁkos VégváriRoman A. ZubarevNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amir Ata Saei Christian Michel Beusch Alexey Chernobrovkin Pierre Sabatier Bo Zhang Ülkü Güler Tokat Eleni Stergiou Massimiliano Gaetani Ákos Végvári Roman A. Zubarev ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
description	Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their mechanisms of action.
format	article
author	Amir Ata Saei Christian Michel Beusch Alexey Chernobrovkin Pierre Sabatier Bo Zhang Ülkü Güler Tokat Eleni Stergiou Massimiliano Gaetani Ákos Végvári Roman A. Zubarev
author_facet	Amir Ata Saei Christian Michel Beusch Alexey Chernobrovkin Pierre Sabatier Bo Zhang Ülkü Güler Tokat Eleni Stergiou Massimiliano Gaetani Ákos Végvári Roman A. Zubarev
author_sort	Amir Ata Saei
title	ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
title_short	ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
title_full	ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
title_fullStr	ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
title_full_unstemmed	ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
title_sort	protargetminer as a proteome signature library of anticancer molecules for functional discovery
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ad0814e6df26497b89b780d2b504f842
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ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery

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