Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.

<h4>Background</h4>International and internal migration are recognized risk factors for tuberculosis (TB). Geographic mobility, including travel for work, education, or personal reasons, may also play a role in TB transmission, but this relationship is poorly defined. We aimed to define...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katherine O Robsky, David Isooba, Olga Nakasolya, James Mukiibi, Annet Nalutaaya, Peter J Kitonsa, Caleb Kamoga, Yeonsoo Baik, Emily A Kendall, Achilles Katamba, David W Dowdy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad098836b1a44c52b94f8f5647d980e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad098836b1a44c52b94f8f5647d980e3
record_format	dspace
spelling	oai:doaj.org-article:ad098836b1a44c52b94f8f5647d980e32021-11-25T06:19:14ZCharacterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.1932-620310.1371/journal.pone.0251806https://doaj.org/article/ad098836b1a44c52b94f8f5647d980e32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251806https://doaj.org/toc/1932-6203<h4>Background</h4>International and internal migration are recognized risk factors for tuberculosis (TB). Geographic mobility, including travel for work, education, or personal reasons, may also play a role in TB transmission, but this relationship is poorly defined. We aimed to define geographic mobility among participants in facility- and community-based TB case finding in Kampala, Uganda, and to assess associations between mobility, access to care, and TB disease.<h4>Methods</h4>We included consecutive individuals age ≥15 years diagnosed with TB disease through either routine health facility practices or community-based case finding (consisting of door-to-door testing, venue-based screening, and contact investigation). Each case was matched with one (for community-based enrollment) or two (health facility enrollment) TB-negative controls. We conducted a latent class analysis (LCA) of eight self-reported characteristics to identify and define mobility; we selected the best-fit model using Bayesian Information Criterion. We assessed associations between mobility and TB case status using multivariable conditional logistic regression.<h4>Results</h4>We enrolled 267 cases and 432 controls. Cases were more likely than controls to have been born in Kampala (p<0.001); there was no difference between cases and controls for remaining mobility characteristics. We selected a two-class LCA model; the "mobile" class was perfectly correlated with a single variable: travel (>3 km) from residence ≥2 times per month. Mobility was associated with a 28% reduction in odds of being a TB case (adjusted matched odds ratio 0.72 [95% confidence interval 0.49, 1.06]).<h4>Conclusion</h4>Frequency of out-of-neighborhood travel is an easily measured variable that correlates closely with predicted mobility class membership. Mobility was associated with decreased risk of TB disease; this may be in part due to the higher socioeconomic status of mobile individuals in this population. However, more research is needed to improve assessment of mobility and understand how mobility affects disease risk and transmission.Katherine O RobskyDavid IsoobaOlga NakasolyaJames MukiibiAnnet NalutaayaPeter J KitonsaCaleb KamogaYeonsoo BaikEmily A KendallAchilles KatambaDavid W DowdyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251806 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katherine O Robsky David Isooba Olga Nakasolya James Mukiibi Annet Nalutaaya Peter J Kitonsa Caleb Kamoga Yeonsoo Baik Emily A Kendall Achilles Katamba David W Dowdy Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
description	<h4>Background</h4>International and internal migration are recognized risk factors for tuberculosis (TB). Geographic mobility, including travel for work, education, or personal reasons, may also play a role in TB transmission, but this relationship is poorly defined. We aimed to define geographic mobility among participants in facility- and community-based TB case finding in Kampala, Uganda, and to assess associations between mobility, access to care, and TB disease.<h4>Methods</h4>We included consecutive individuals age ≥15 years diagnosed with TB disease through either routine health facility practices or community-based case finding (consisting of door-to-door testing, venue-based screening, and contact investigation). Each case was matched with one (for community-based enrollment) or two (health facility enrollment) TB-negative controls. We conducted a latent class analysis (LCA) of eight self-reported characteristics to identify and define mobility; we selected the best-fit model using Bayesian Information Criterion. We assessed associations between mobility and TB case status using multivariable conditional logistic regression.<h4>Results</h4>We enrolled 267 cases and 432 controls. Cases were more likely than controls to have been born in Kampala (p<0.001); there was no difference between cases and controls for remaining mobility characteristics. We selected a two-class LCA model; the "mobile" class was perfectly correlated with a single variable: travel (>3 km) from residence ≥2 times per month. Mobility was associated with a 28% reduction in odds of being a TB case (adjusted matched odds ratio 0.72 [95% confidence interval 0.49, 1.06]).<h4>Conclusion</h4>Frequency of out-of-neighborhood travel is an easily measured variable that correlates closely with predicted mobility class membership. Mobility was associated with decreased risk of TB disease; this may be in part due to the higher socioeconomic status of mobile individuals in this population. However, more research is needed to improve assessment of mobility and understand how mobility affects disease risk and transmission.
format	article
author	Katherine O Robsky David Isooba Olga Nakasolya James Mukiibi Annet Nalutaaya Peter J Kitonsa Caleb Kamoga Yeonsoo Baik Emily A Kendall Achilles Katamba David W Dowdy
author_facet	Katherine O Robsky David Isooba Olga Nakasolya James Mukiibi Annet Nalutaaya Peter J Kitonsa Caleb Kamoga Yeonsoo Baik Emily A Kendall Achilles Katamba David W Dowdy
author_sort	Katherine O Robsky
title	Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
title_short	Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
title_full	Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
title_fullStr	Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
title_full_unstemmed	Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.
title_sort	characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban uganda.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ad098836b1a44c52b94f8f5647d980e3
work_keys_str_mv	AT katherineorobsky characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT davidisooba characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT olganakasolya characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT jamesmukiibi characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT annetnalutaaya characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT peterjkitonsa characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT calebkamoga characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT yeonsoobaik characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT emilyakendall characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT achilleskatamba characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda AT davidwdowdy characterizationofgeographicmobilityamongparticipantsinfacilityandcommunitybasedtuberculosiscasefindinginurbanuganda
_version_	1718413944617435136

Characterization of geographic mobility among participants in facility- and community-based tuberculosis case finding in urban Uganda.

Ejemplares similares